Dominant expression of multidrug resistance in intraspecific murine lymphoma hybrid cells

István Pályi, Gizella Turi, Lehel Hullán, Károly Szikla, Mihály Bak

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cultured P388/VCR mouse lymphoma cells resistant to vincristine (VCR) and to 5-bromodeoxyuridine (BUdR) and deficient in thymidine kinase (TK-) were fused with P388/DAG cells resistant to 1,2:5,6-dianhydrogalactitol (DAG), an anticancer alkylating agent, and to 6-thioguanine (6-TG) and deficient in hypoxanthine phosphoribosyl-transferase (HPRT-). The hybrid cells expressed multidrug resistance (MDR), i.e., resistance to VCR and cross-resistance to Adriamycin (ADM) and actinomycin D (Act. D), in a dominant manner. The presence of glycoprotein p170, the MDR gene product, was detected in the hybrid cells. Resistance to DAG was also expressed dominantly, whereas cross-resistance to dibromodulcitol (DBD), a chemically related anticancer drug, was slight.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalCancer Chemotherapy And Pharmacology
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 1 1994

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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