Does the endoscopic appearance of the ileocecal valve suggest the severity of Crohn's disease in the terminal ileum?

T. Molnár, Klaudia Farkas, F. Nagy, Zoltán Szepes, L. Tiszlavicz, István Németh, T. Nyári, T. Wittmann

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Despite ileoscopy being the only procedure, which can accurately detect mucosal abnormalities in the ileum, it is performed only in 5-15% of the colonoscopies. Aim: The aim of this study was to retrospectively determine the predictive value of the endoscopic findings of the ileocecal valve (ICV) in patients with CD. Methods: Data of 100 ileal or ileocolonic CD patients (45 females, 55 males, mean age 27.6 years, range 5-66), who underwent ileocolonoscopy between 2004 and 2008, were reviewed. Macroscopic appearance of the ICV and the endoscopic severity of the ileum evaluated by the Simple Endoscopic Score for Crohn's Disease were determined by re-evaluating the examinations recorded on DVDs in all cases. Histological scoring was performed in 56 cases. Statistical analyses were performed to assess relationships between the normal-looking ICV and the histological and endoscopic scores of the ileum and the correlation between the severity of the ileal inflammation and the macroscopic appearance of the ICV. Results: A macroscopically normal appearance of the ICV was detected in 30 patients. 60% of these patients were diagnosed with mild, 26.7% with moderate and 13.3% with severe endoscopic ileal inflammation. ICV was affected by CD in 70 patients, in whom significantly more severe ileal inflammation (p = 0.005) was detected than in patients with normal-looking ICV. Discussion: Our results suggest that ileal exploration should be attempted in every suspected CD patients, because, although the appearance of the ICV correlates with the severity of the ileal inflammation, a normal-looking ICV does not correspond to normal ileal mucosa in almost one third of the cases.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalJournal of Crohn's and Colitis
Volume3
Issue number4
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Ileocecal Valve
Ileum
Crohn Disease
Inflammation
Colonoscopy
Mucous Membrane

Keywords

  • Crohn's disease
  • Ileocecal valve
  • Ileoscopy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Does the endoscopic appearance of the ileocecal valve suggest the severity of Crohn's disease in the terminal ileum? / Molnár, T.; Farkas, Klaudia; Nagy, F.; Szepes, Zoltán; Tiszlavicz, L.; Németh, István; Nyári, T.; Wittmann, T.

In: Journal of Crohn's and Colitis, Vol. 3, No. 4, 12.2009, p. 287-290.

Research output: Contribution to journalArticle

@article{b891c4c02cfa4b7b95c8598e815afe49,
title = "Does the endoscopic appearance of the ileocecal valve suggest the severity of Crohn's disease in the terminal ileum?",
abstract = "Despite ileoscopy being the only procedure, which can accurately detect mucosal abnormalities in the ileum, it is performed only in 5-15{\%} of the colonoscopies. Aim: The aim of this study was to retrospectively determine the predictive value of the endoscopic findings of the ileocecal valve (ICV) in patients with CD. Methods: Data of 100 ileal or ileocolonic CD patients (45 females, 55 males, mean age 27.6 years, range 5-66), who underwent ileocolonoscopy between 2004 and 2008, were reviewed. Macroscopic appearance of the ICV and the endoscopic severity of the ileum evaluated by the Simple Endoscopic Score for Crohn's Disease were determined by re-evaluating the examinations recorded on DVDs in all cases. Histological scoring was performed in 56 cases. Statistical analyses were performed to assess relationships between the normal-looking ICV and the histological and endoscopic scores of the ileum and the correlation between the severity of the ileal inflammation and the macroscopic appearance of the ICV. Results: A macroscopically normal appearance of the ICV was detected in 30 patients. 60{\%} of these patients were diagnosed with mild, 26.7{\%} with moderate and 13.3{\%} with severe endoscopic ileal inflammation. ICV was affected by CD in 70 patients, in whom significantly more severe ileal inflammation (p = 0.005) was detected than in patients with normal-looking ICV. Discussion: Our results suggest that ileal exploration should be attempted in every suspected CD patients, because, although the appearance of the ICV correlates with the severity of the ileal inflammation, a normal-looking ICV does not correspond to normal ileal mucosa in almost one third of the cases.",
keywords = "Crohn's disease, Ileocecal valve, Ileoscopy",
author = "T. Moln{\'a}r and Klaudia Farkas and F. Nagy and Zolt{\'a}n Szepes and L. Tiszlavicz and Istv{\'a}n N{\'e}meth and T. Ny{\'a}ri and T. Wittmann",
year = "2009",
month = "12",
doi = "10.1016/j.crohns.2009.08.001",
language = "English",
volume = "3",
pages = "287--290",
journal = "Journal of Crohn's and Colitis",
issn = "1873-9946",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Does the endoscopic appearance of the ileocecal valve suggest the severity of Crohn's disease in the terminal ileum?

AU - Molnár, T.

AU - Farkas, Klaudia

AU - Nagy, F.

AU - Szepes, Zoltán

AU - Tiszlavicz, L.

AU - Németh, István

AU - Nyári, T.

AU - Wittmann, T.

PY - 2009/12

Y1 - 2009/12

N2 - Despite ileoscopy being the only procedure, which can accurately detect mucosal abnormalities in the ileum, it is performed only in 5-15% of the colonoscopies. Aim: The aim of this study was to retrospectively determine the predictive value of the endoscopic findings of the ileocecal valve (ICV) in patients with CD. Methods: Data of 100 ileal or ileocolonic CD patients (45 females, 55 males, mean age 27.6 years, range 5-66), who underwent ileocolonoscopy between 2004 and 2008, were reviewed. Macroscopic appearance of the ICV and the endoscopic severity of the ileum evaluated by the Simple Endoscopic Score for Crohn's Disease were determined by re-evaluating the examinations recorded on DVDs in all cases. Histological scoring was performed in 56 cases. Statistical analyses were performed to assess relationships between the normal-looking ICV and the histological and endoscopic scores of the ileum and the correlation between the severity of the ileal inflammation and the macroscopic appearance of the ICV. Results: A macroscopically normal appearance of the ICV was detected in 30 patients. 60% of these patients were diagnosed with mild, 26.7% with moderate and 13.3% with severe endoscopic ileal inflammation. ICV was affected by CD in 70 patients, in whom significantly more severe ileal inflammation (p = 0.005) was detected than in patients with normal-looking ICV. Discussion: Our results suggest that ileal exploration should be attempted in every suspected CD patients, because, although the appearance of the ICV correlates with the severity of the ileal inflammation, a normal-looking ICV does not correspond to normal ileal mucosa in almost one third of the cases.

AB - Despite ileoscopy being the only procedure, which can accurately detect mucosal abnormalities in the ileum, it is performed only in 5-15% of the colonoscopies. Aim: The aim of this study was to retrospectively determine the predictive value of the endoscopic findings of the ileocecal valve (ICV) in patients with CD. Methods: Data of 100 ileal or ileocolonic CD patients (45 females, 55 males, mean age 27.6 years, range 5-66), who underwent ileocolonoscopy between 2004 and 2008, were reviewed. Macroscopic appearance of the ICV and the endoscopic severity of the ileum evaluated by the Simple Endoscopic Score for Crohn's Disease were determined by re-evaluating the examinations recorded on DVDs in all cases. Histological scoring was performed in 56 cases. Statistical analyses were performed to assess relationships between the normal-looking ICV and the histological and endoscopic scores of the ileum and the correlation between the severity of the ileal inflammation and the macroscopic appearance of the ICV. Results: A macroscopically normal appearance of the ICV was detected in 30 patients. 60% of these patients were diagnosed with mild, 26.7% with moderate and 13.3% with severe endoscopic ileal inflammation. ICV was affected by CD in 70 patients, in whom significantly more severe ileal inflammation (p = 0.005) was detected than in patients with normal-looking ICV. Discussion: Our results suggest that ileal exploration should be attempted in every suspected CD patients, because, although the appearance of the ICV correlates with the severity of the ileal inflammation, a normal-looking ICV does not correspond to normal ileal mucosa in almost one third of the cases.

KW - Crohn's disease

KW - Ileocecal valve

KW - Ileoscopy

UR - http://www.scopus.com/inward/record.url?scp=70350618496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350618496&partnerID=8YFLogxK

U2 - 10.1016/j.crohns.2009.08.001

DO - 10.1016/j.crohns.2009.08.001

M3 - Article

C2 - 21172289

AN - SCOPUS:70350618496

VL - 3

SP - 287

EP - 290

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

IS - 4

ER -