Does the chronically inflamed periodontium harbour cancer stem cells?

Wolf Dieter Grimm, Wolfgang H. Arnold, Sebastian Becher, Aous Dannan, Georg Gassmann, Stathis Philippou, Thomas Dittmar, G. Varga

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Trials aiming at isolating cultures and subcultures of cells from the periodontal ligament to uncover special features of such tissue-residing population are related to the past decade [1]. Moreover, the idea of cell-delivery systems, and especially with stem cells, to initiate periodontal regeneration is not new. However, describing suitable animal models for such new techniques is less documented in the literature and sometimes underestimated. The wide range of animal species allows appropriate selection of bio-models for different investigations. Each species has unique similarities and dissimilarities to humans. While many studies could ensure the initiation of periodontal regeneration using stem cells extracted from the periodontium, seeding of human periodontium-derived stem cells (pdSCs) on collagen carriers could induce major features of periodontal regeneration when implanted in experimental periodontal defects in the athymic immunodeficient rat as could be shown in our studies. However, remarkable notifications regarding the results obtained in our studies were the induction of malignant tumors (squamous cell carcinoma) in the majority of investigated animals. Considering the data presented in the literature, our studies seems to be the first that demonstrates the initiation of malignant tumors when using human pdSCs. The patients from whom the pdSCs had been extracted, the animal model used and a possible oncogenic alteration of the pdSCs themselves might all be factors behind the tumors' initiation. In our present studies, the animal model used and the related experimental periodontal defect, as a heterologous model, could successfully present two important biological features after implantation of pdSCs; namely periodontal repair and tumorigenicity. Although not fully histo-morphometrically assessed in our studies, these features are very important for further investigations and for future more-controlled studies. However, further studies using advanced histological, immunological and genetic techniques are required to assure different supposals presented in the current studies regarding stem cell-based periodontal regeneration and stem cell-tumorigenesis.

Original languageEnglish
Title of host publicationStem Cell Biology in Health and Disease
PublisherSpringer Netherlands
Pages251-279
Number of pages29
ISBN (Print)9789048130399
DOIs
Publication statusPublished - 2009

Fingerprint

Periodontium
Neoplastic Stem Cells
Ports and harbors
Stem cells
Stem Cells
Animals
Regeneration
Tumors
Animal Models
Nude Rats
Immunologic Techniques
Histological Techniques
Genetic Techniques
Neoplasms
Periodontal Ligament
Defects
Ligaments
Cell culture
Rats
Squamous Cell Carcinoma

Keywords

  • Animal models in periodontal research
  • Athymic immunodeficient rat
  • Human periodontium-derived stem cells (pdSCs)
  • Mesenchymal stem cells
  • Minimally-invasive periodontal surgical therapy
  • Osteogenic differentiation
  • Periodontal tissue regeneration
  • Periodontium
  • Tumorogenicity neural stemness markers

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Grimm, W. D., Arnold, W. H., Becher, S., Dannan, A., Gassmann, G., Philippou, S., ... Varga, G. (2009). Does the chronically inflamed periodontium harbour cancer stem cells? In Stem Cell Biology in Health and Disease (pp. 251-279). Springer Netherlands. https://doi.org/10.1007/978-90-481-3040-5_12

Does the chronically inflamed periodontium harbour cancer stem cells? / Grimm, Wolf Dieter; Arnold, Wolfgang H.; Becher, Sebastian; Dannan, Aous; Gassmann, Georg; Philippou, Stathis; Dittmar, Thomas; Varga, G.

Stem Cell Biology in Health and Disease. Springer Netherlands, 2009. p. 251-279.

Research output: Chapter in Book/Report/Conference proceedingChapter

Grimm, WD, Arnold, WH, Becher, S, Dannan, A, Gassmann, G, Philippou, S, Dittmar, T & Varga, G 2009, Does the chronically inflamed periodontium harbour cancer stem cells? in Stem Cell Biology in Health and Disease. Springer Netherlands, pp. 251-279. https://doi.org/10.1007/978-90-481-3040-5_12
Grimm WD, Arnold WH, Becher S, Dannan A, Gassmann G, Philippou S et al. Does the chronically inflamed periodontium harbour cancer stem cells? In Stem Cell Biology in Health and Disease. Springer Netherlands. 2009. p. 251-279 https://doi.org/10.1007/978-90-481-3040-5_12
Grimm, Wolf Dieter ; Arnold, Wolfgang H. ; Becher, Sebastian ; Dannan, Aous ; Gassmann, Georg ; Philippou, Stathis ; Dittmar, Thomas ; Varga, G. / Does the chronically inflamed periodontium harbour cancer stem cells?. Stem Cell Biology in Health and Disease. Springer Netherlands, 2009. pp. 251-279
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