Does 3H-imipramine binding asymmetry indicate psychiatric illness?

E. Demeter, K. Tekes, K. Majorossy, M. Arato, E. Somogyi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We have accepted that serotonin is essentially an inhibitory neurotransmitter in human brain, so we propose that it is precisely this inhibiting effect that has weakened in psychiatry cases. We have investigated the asymmetry of tritiated imipramine binding sites (Bmax) in the frontal cortices of homicide victims (n = 6) and controls (n = 6) who died of natural causes. Of these homicide victims examined in our experiment, five proved to have been psychiatric cases and one case had no psychiatric record. The two groups were comparable in age, gender and postmortem delay. The number of imipramine binding sites (Bmax) in the frontal cortices of controls was significantly higher in the right hemisphere than in the left hemisphere. But the homicide victims who were psychiatric cases had significantly higher (Bmax) values in the left hemisphere. While we only found higher Bmax values in the left hemisphere of homicide victims with mental diseases, our data may serve to prove the direct role of the serotonergic mechanism in the development of psychiatric cases.

Original languageEnglish
Pages (from-to)746-747
Number of pages2
JournalActa Psychiatrica Scandinavica
Volume77
Issue number6
Publication statusPublished - 1988

Fingerprint

Imipramine
Homicide
Psychiatry
Frontal Lobe
Binding Sites
Neurotransmitter Agents
Serotonin
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Demeter, E., Tekes, K., Majorossy, K., Arato, M., & Somogyi, E. (1988). Does 3H-imipramine binding asymmetry indicate psychiatric illness? Acta Psychiatrica Scandinavica, 77(6), 746-747.

Does 3H-imipramine binding asymmetry indicate psychiatric illness? / Demeter, E.; Tekes, K.; Majorossy, K.; Arato, M.; Somogyi, E.

In: Acta Psychiatrica Scandinavica, Vol. 77, No. 6, 1988, p. 746-747.

Research output: Contribution to journalArticle

Demeter, E, Tekes, K, Majorossy, K, Arato, M & Somogyi, E 1988, 'Does 3H-imipramine binding asymmetry indicate psychiatric illness?', Acta Psychiatrica Scandinavica, vol. 77, no. 6, pp. 746-747.
Demeter, E. ; Tekes, K. ; Majorossy, K. ; Arato, M. ; Somogyi, E. / Does 3H-imipramine binding asymmetry indicate psychiatric illness?. In: Acta Psychiatrica Scandinavica. 1988 ; Vol. 77, No. 6. pp. 746-747.
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