Does gender have prognostic value among patients with myocardial infarction? Analysis of the data from the Hungarian myocardial infarction registry

A. Jánosi, Tamás Ferenci, Péter Ofner, Géza Lupkovics, Dávid Becker, József Faluközy, Péter Polgár, Zsolt Koszegi, I. Horváth, Z. Jambrik, Veronika Szentes, B. Merkely, Csaba András Dézsi

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Abstract

Background: The authors analyzed data from the Hungarian Myocardial Infarction Registry (HUMIR) to examine the potential impact of gender on the treatment and 30-day and 1-year mortality of patients with myocardial infarction (MI). Materials and Methods: The National Registry of Myocardial Infarction included 42,953 patients between January 1, 2013 and December 31, 2016; 19,875 of whom were diagnosed with ST-elevation myocardial infarction (STEMI) and 23,078 with non-ST-elevation myocardial infarction (NSTEMI). The proportion of women was 39% and 41.9% in the two groups, respectively. Logistic regression analysis was performed adjusting for age, the year and month of hospital admission, smoking, as well as for five concomitant diseases and anamnestic data. We found that the odds ratio (OR) of performing percutaneous coronary intervention (PCI) was influenced by age, the year of treatment, prior stroke, and peripheral artery disease (PAD) in both patient groups. Results: Gender had an impact on treatment in both cases; women had significantly fewer PCIs (OR = 0.86 confidence interval [95% CI: 0.77-0.95] in the STEMI group, OR = 0.75 [95% CI: 0.70-0.82] in the NSTEMI group). Age and PCI, PAD, and diabetes mellitus proved to be prognostic factors for 30-day and 1-year mortality in both groups. In the STEMI group, hypertension proved to be of prognostic value for both 30-day and 1-year mortality, whereas prior MI, stroke, and smoking only affected 1-year mortality. Similarly, in the NSTEMI group, prior stroke was also of prognostic value for 30-day and 1-year mortality, whereas prior MI, hypertension and smoking were only associated with 1-year mortality. Conclusions: The independent prognostic value of gender could not be proven for any of the MI types or follow-up periods. In conclusion, gender influenced the treatment of patients with MI but had no significant impact on prognosis in itself.

Original languageEnglish
Pages (from-to)1491-1498
Number of pages8
JournalJournal of Women's Health
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 1 2018

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Registries
Myocardial Infarction
Mortality
Smoking
Peripheral Arterial Disease
Stroke
Odds Ratio
Percutaneous Coronary Intervention
Hypertension
Therapeutics
Diabetes Mellitus
Logistic Models
Regression Analysis
Confidence Intervals
Non-ST Elevated Myocardial Infarction
ST Elevation Myocardial Infarction

Keywords

  • gender difference
  • mortality
  • myocardial infarction
  • percutaneous coronary intervention
  • prognosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Does gender have prognostic value among patients with myocardial infarction? Analysis of the data from the Hungarian myocardial infarction registry. / Jánosi, A.; Ferenci, Tamás; Ofner, Péter; Lupkovics, Géza; Becker, Dávid; Faluközy, József; Polgár, Péter; Koszegi, Zsolt; Horváth, I.; Jambrik, Z.; Szentes, Veronika; Merkely, B.; Dézsi, Csaba András.

In: Journal of Women's Health, Vol. 27, No. 12, 01.12.2018, p. 1491-1498.

Research output: Contribution to journalArticle

Jánosi, A. ; Ferenci, Tamás ; Ofner, Péter ; Lupkovics, Géza ; Becker, Dávid ; Faluközy, József ; Polgár, Péter ; Koszegi, Zsolt ; Horváth, I. ; Jambrik, Z. ; Szentes, Veronika ; Merkely, B. ; Dézsi, Csaba András. / Does gender have prognostic value among patients with myocardial infarction? Analysis of the data from the Hungarian myocardial infarction registry. In: Journal of Women's Health. 2018 ; Vol. 27, No. 12. pp. 1491-1498.
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abstract = "Background: The authors analyzed data from the Hungarian Myocardial Infarction Registry (HUMIR) to examine the potential impact of gender on the treatment and 30-day and 1-year mortality of patients with myocardial infarction (MI). Materials and Methods: The National Registry of Myocardial Infarction included 42,953 patients between January 1, 2013 and December 31, 2016; 19,875 of whom were diagnosed with ST-elevation myocardial infarction (STEMI) and 23,078 with non-ST-elevation myocardial infarction (NSTEMI). The proportion of women was 39{\%} and 41.9{\%} in the two groups, respectively. Logistic regression analysis was performed adjusting for age, the year and month of hospital admission, smoking, as well as for five concomitant diseases and anamnestic data. We found that the odds ratio (OR) of performing percutaneous coronary intervention (PCI) was influenced by age, the year of treatment, prior stroke, and peripheral artery disease (PAD) in both patient groups. Results: Gender had an impact on treatment in both cases; women had significantly fewer PCIs (OR = 0.86 confidence interval [95{\%} CI: 0.77-0.95] in the STEMI group, OR = 0.75 [95{\%} CI: 0.70-0.82] in the NSTEMI group). Age and PCI, PAD, and diabetes mellitus proved to be prognostic factors for 30-day and 1-year mortality in both groups. In the STEMI group, hypertension proved to be of prognostic value for both 30-day and 1-year mortality, whereas prior MI, stroke, and smoking only affected 1-year mortality. Similarly, in the NSTEMI group, prior stroke was also of prognostic value for 30-day and 1-year mortality, whereas prior MI, hypertension and smoking were only associated with 1-year mortality. Conclusions: The independent prognostic value of gender could not be proven for any of the MI types or follow-up periods. In conclusion, gender influenced the treatment of patients with MI but had no significant impact on prognosis in itself.",
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T1 - Does gender have prognostic value among patients with myocardial infarction? Analysis of the data from the Hungarian myocardial infarction registry

AU - Jánosi, A.

AU - Ferenci, Tamás

AU - Ofner, Péter

AU - Lupkovics, Géza

AU - Becker, Dávid

AU - Faluközy, József

AU - Polgár, Péter

AU - Koszegi, Zsolt

AU - Horváth, I.

AU - Jambrik, Z.

AU - Szentes, Veronika

AU - Merkely, B.

AU - Dézsi, Csaba András

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: The authors analyzed data from the Hungarian Myocardial Infarction Registry (HUMIR) to examine the potential impact of gender on the treatment and 30-day and 1-year mortality of patients with myocardial infarction (MI). Materials and Methods: The National Registry of Myocardial Infarction included 42,953 patients between January 1, 2013 and December 31, 2016; 19,875 of whom were diagnosed with ST-elevation myocardial infarction (STEMI) and 23,078 with non-ST-elevation myocardial infarction (NSTEMI). The proportion of women was 39% and 41.9% in the two groups, respectively. Logistic regression analysis was performed adjusting for age, the year and month of hospital admission, smoking, as well as for five concomitant diseases and anamnestic data. We found that the odds ratio (OR) of performing percutaneous coronary intervention (PCI) was influenced by age, the year of treatment, prior stroke, and peripheral artery disease (PAD) in both patient groups. Results: Gender had an impact on treatment in both cases; women had significantly fewer PCIs (OR = 0.86 confidence interval [95% CI: 0.77-0.95] in the STEMI group, OR = 0.75 [95% CI: 0.70-0.82] in the NSTEMI group). Age and PCI, PAD, and diabetes mellitus proved to be prognostic factors for 30-day and 1-year mortality in both groups. In the STEMI group, hypertension proved to be of prognostic value for both 30-day and 1-year mortality, whereas prior MI, stroke, and smoking only affected 1-year mortality. Similarly, in the NSTEMI group, prior stroke was also of prognostic value for 30-day and 1-year mortality, whereas prior MI, hypertension and smoking were only associated with 1-year mortality. Conclusions: The independent prognostic value of gender could not be proven for any of the MI types or follow-up periods. In conclusion, gender influenced the treatment of patients with MI but had no significant impact on prognosis in itself.

AB - Background: The authors analyzed data from the Hungarian Myocardial Infarction Registry (HUMIR) to examine the potential impact of gender on the treatment and 30-day and 1-year mortality of patients with myocardial infarction (MI). Materials and Methods: The National Registry of Myocardial Infarction included 42,953 patients between January 1, 2013 and December 31, 2016; 19,875 of whom were diagnosed with ST-elevation myocardial infarction (STEMI) and 23,078 with non-ST-elevation myocardial infarction (NSTEMI). The proportion of women was 39% and 41.9% in the two groups, respectively. Logistic regression analysis was performed adjusting for age, the year and month of hospital admission, smoking, as well as for five concomitant diseases and anamnestic data. We found that the odds ratio (OR) of performing percutaneous coronary intervention (PCI) was influenced by age, the year of treatment, prior stroke, and peripheral artery disease (PAD) in both patient groups. Results: Gender had an impact on treatment in both cases; women had significantly fewer PCIs (OR = 0.86 confidence interval [95% CI: 0.77-0.95] in the STEMI group, OR = 0.75 [95% CI: 0.70-0.82] in the NSTEMI group). Age and PCI, PAD, and diabetes mellitus proved to be prognostic factors for 30-day and 1-year mortality in both groups. In the STEMI group, hypertension proved to be of prognostic value for both 30-day and 1-year mortality, whereas prior MI, stroke, and smoking only affected 1-year mortality. Similarly, in the NSTEMI group, prior stroke was also of prognostic value for 30-day and 1-year mortality, whereas prior MI, hypertension and smoking were only associated with 1-year mortality. Conclusions: The independent prognostic value of gender could not be proven for any of the MI types or follow-up periods. In conclusion, gender influenced the treatment of patients with MI but had no significant impact on prognosis in itself.

KW - gender difference

KW - mortality

KW - myocardial infarction

KW - percutaneous coronary intervention

KW - prognosis

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