Does carbamazepine-epoxide conjugate with glutathione? On an existing but almost forgotten possibility

M. Kalapos, J. Debreczeni, K. Szell, S. Olajos, I. Herczeg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The anticonvulsant carbamazepine is widely used to treat affective disorders and behavioural disorders in non-epileptic children. We report an elevated plasma level of carbamazepine-10,11-epoxide in a cystinuric child after daily medication with 300 mg carbamazepine while the serum level of carbamazepine was in the therapeutic range. The concentrations of carbamazepine and its epoxide derivative were determined by HPLC. The formation of a glutathione conjugate of carbamazepine-10,11-epoxide is raised as a hypothesis.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalDrug Metabolism and Drug Interactions
Volume16
Issue number3
Publication statusPublished - 2000

Fingerprint

Carbamazepine
Glutathione
Mood Disorders
Anticonvulsants
High Pressure Liquid Chromatography
Serum
carbamazepine epoxide
Therapeutics

Keywords

  • Carbamazepine
  • Carbamazepine-10,11-epoxide
  • Cystinuria
  • Glutathione

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Does carbamazepine-epoxide conjugate with glutathione? On an existing but almost forgotten possibility. / Kalapos, M.; Debreczeni, J.; Szell, K.; Olajos, S.; Herczeg, I.

In: Drug Metabolism and Drug Interactions, Vol. 16, No. 3, 2000, p. 229-235.

Research output: Contribution to journalArticle

Kalapos, M. ; Debreczeni, J. ; Szell, K. ; Olajos, S. ; Herczeg, I. / Does carbamazepine-epoxide conjugate with glutathione? On an existing but almost forgotten possibility. In: Drug Metabolism and Drug Interactions. 2000 ; Vol. 16, No. 3. pp. 229-235.
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