Does borderline kidney allograft rejection always require treatment?

Dorottya Németh, Jörg Ovens, Gerhard Opelz, Claudia Sommerer, Bernd Döhler, Luis E. Becker, Marie Luise Gross, Rüdiger Waldherr, Markus Mieth, Mahmoud Sadeghi, Jan Schmidt, R. Langer, Martin Zeier, Caner Süsal

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background. Borderline rejection (Bord-R) is a frequent diagnosis in renal transplantation, and there is increasing evidence that regulatory T lymphocytes are involved in its pathogenesis. Current histopathologic practice does not differentiate between graft-protecting and-damaging T lymphocytes, and patients with Bord-R routinely receive rejection treatment. We analyzed Treg-associated forkhead box P3 (Foxp3) gene expression in Bord-R and more severe forms of acute rejection episodes (ARE). Methods. Foxp3 transcripts were measured in 520 serial peripheral blood samples from 177 kidney graft recipients obtained during the first 20 days posttransplantation. Results. The highest Foxp3 transcripts were observed in patients with Bord-R or without rejection and the lowest in patients with ARE. Patients with Bord-R on posttransplant days 5 to 7 showed an increased Foxp3 transcript level of 156%, which increased to 302% by posttransplant days 14 to 16. In contrast, patients with ARE demonstrated significantly lower Foxp3 gene expression than that observed in Bord-R, nonrejectors, or acute tubular necrosis patients (P=0.001, P

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalTransplantation
Volume90
Issue number4
DOIs
Publication statusPublished - Aug 27 2010

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Allografts
Kidney
Therapeutics
Transplants
Gene Expression
Regulatory T-Lymphocytes
Kidney Transplantation
Necrosis
T-Lymphocytes

Keywords

  • Borderline rejection
  • Foxp3
  • Kidney transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Németh, D., Ovens, J., Opelz, G., Sommerer, C., Döhler, B., Becker, L. E., ... Süsal, C. (2010). Does borderline kidney allograft rejection always require treatment? Transplantation, 90(4), 427-432. https://doi.org/10.1097/TP.0b013e3181e81b16

Does borderline kidney allograft rejection always require treatment? / Németh, Dorottya; Ovens, Jörg; Opelz, Gerhard; Sommerer, Claudia; Döhler, Bernd; Becker, Luis E.; Gross, Marie Luise; Waldherr, Rüdiger; Mieth, Markus; Sadeghi, Mahmoud; Schmidt, Jan; Langer, R.; Zeier, Martin; Süsal, Caner.

In: Transplantation, Vol. 90, No. 4, 27.08.2010, p. 427-432.

Research output: Contribution to journalArticle

Németh, D, Ovens, J, Opelz, G, Sommerer, C, Döhler, B, Becker, LE, Gross, ML, Waldherr, R, Mieth, M, Sadeghi, M, Schmidt, J, Langer, R, Zeier, M & Süsal, C 2010, 'Does borderline kidney allograft rejection always require treatment?', Transplantation, vol. 90, no. 4, pp. 427-432. https://doi.org/10.1097/TP.0b013e3181e81b16
Németh D, Ovens J, Opelz G, Sommerer C, Döhler B, Becker LE et al. Does borderline kidney allograft rejection always require treatment? Transplantation. 2010 Aug 27;90(4):427-432. https://doi.org/10.1097/TP.0b013e3181e81b16
Németh, Dorottya ; Ovens, Jörg ; Opelz, Gerhard ; Sommerer, Claudia ; Döhler, Bernd ; Becker, Luis E. ; Gross, Marie Luise ; Waldherr, Rüdiger ; Mieth, Markus ; Sadeghi, Mahmoud ; Schmidt, Jan ; Langer, R. ; Zeier, Martin ; Süsal, Caner. / Does borderline kidney allograft rejection always require treatment?. In: Transplantation. 2010 ; Vol. 90, No. 4. pp. 427-432.
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