Does body mass index associate with the endoscopic severity of gastroesophageal reflux disease?

Research output: Contribution to journalArticle

Abstract

To evaluate the association between body mass index (BMI) and gastroesophageal reflux disease (GERD) severity in the group of patients frequently suffering from moderate/severe gastroesophageal reflux symptoms, one hundred and fifty eight previously untreated patients underwent upper panendoscopy as indicated by typical moderate/severe reflux symptoms, occurring three or more times per week. Patients' BMI values were tabulated and compared to the severity of endoscopic findings (according to Savary-Miller/modified by Siewert). Association between reflux disease activity and BMI was analyzed by Kruskall-Wallis test, while mild and severe group were compared using Mann Whitney test. Analyzing the whole group, including the patients who had no endoscopically verified erosions (Savary-Miller 0 stage = non erosive reflux disease/NERD) association was found at the level of perceivable statistical significance (p=0.0501). However subdividing the examined population into mild (Savary-Miller 0-1 stage) and severe (Savary-Miller 2-4 stage) groups according to the endoscopically verified mucosal lesions of the esophagus, there was a strong significant relationship between severity of GERD and BMI (p=0.0056). In the group of patients with moderate and severe GERD symptoms elevation of BMI can be a risk factor of increased severity of GERD particularly in those who already have erosive mucosal lesions at the time of examination.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalInternational Journal of Diabetes and Metabolism
Volume12
Issue number3
Publication statusPublished - Dec 2004

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Gastroesophageal Reflux
Body Mass Index
Esophagus
Population

Keywords

  • Association
  • Body mass index
  • Gastroesophageal reflux disease
  • Severity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Does body mass index associate with the endoscopic severity of gastroesophageal reflux disease?",
abstract = "To evaluate the association between body mass index (BMI) and gastroesophageal reflux disease (GERD) severity in the group of patients frequently suffering from moderate/severe gastroesophageal reflux symptoms, one hundred and fifty eight previously untreated patients underwent upper panendoscopy as indicated by typical moderate/severe reflux symptoms, occurring three or more times per week. Patients' BMI values were tabulated and compared to the severity of endoscopic findings (according to Savary-Miller/modified by Siewert). Association between reflux disease activity and BMI was analyzed by Kruskall-Wallis test, while mild and severe group were compared using Mann Whitney test. Analyzing the whole group, including the patients who had no endoscopically verified erosions (Savary-Miller 0 stage = non erosive reflux disease/NERD) association was found at the level of perceivable statistical significance (p=0.0501). However subdividing the examined population into mild (Savary-Miller 0-1 stage) and severe (Savary-Miller 2-4 stage) groups according to the endoscopically verified mucosal lesions of the esophagus, there was a strong significant relationship between severity of GERD and BMI (p=0.0056). In the group of patients with moderate and severe GERD symptoms elevation of BMI can be a risk factor of increased severity of GERD particularly in those who already have erosive mucosal lesions at the time of examination.",
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AB - To evaluate the association between body mass index (BMI) and gastroesophageal reflux disease (GERD) severity in the group of patients frequently suffering from moderate/severe gastroesophageal reflux symptoms, one hundred and fifty eight previously untreated patients underwent upper panendoscopy as indicated by typical moderate/severe reflux symptoms, occurring three or more times per week. Patients' BMI values were tabulated and compared to the severity of endoscopic findings (according to Savary-Miller/modified by Siewert). Association between reflux disease activity and BMI was analyzed by Kruskall-Wallis test, while mild and severe group were compared using Mann Whitney test. Analyzing the whole group, including the patients who had no endoscopically verified erosions (Savary-Miller 0 stage = non erosive reflux disease/NERD) association was found at the level of perceivable statistical significance (p=0.0501). However subdividing the examined population into mild (Savary-Miller 0-1 stage) and severe (Savary-Miller 2-4 stage) groups according to the endoscopically verified mucosal lesions of the esophagus, there was a strong significant relationship between severity of GERD and BMI (p=0.0056). In the group of patients with moderate and severe GERD symptoms elevation of BMI can be a risk factor of increased severity of GERD particularly in those who already have erosive mucosal lesions at the time of examination.

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