Documentation of functional and clinical effects of infant nutrition: Setting the scene for COMMENT

Berthold Koletzko, Hania Szajewska, Margaret Ashwell, Raanan Shamir, Peter Aggett, Kurt Baerlocher, Paul Noakes, Christian Braegger, Philip Calder, Cristina Campoy Folgoso, Virginie Colomb, Tamás Decsi, Magnus Domellöf, Christophe Dupont, Mary Fewtrell, Johannes B. Van Goudoever, Kim F. Michaelsen, Walter Mihatsch, Alfredo Guarino, Sibylle KoletzkoJacques Rigo, Dominique Turck, Jan Taminiau

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The Early Nutrition Academy and the Child Health Foundation, in collaboration with the Committee on Nutrition, European Society for Paediatric Gastroenterology, Hepatology and Nutrition, held a workshop in March 2011 to explore guidance on acquiring evidence on the effects of nutritional interventions in infants and young children. The four objectives were to (1) provide guidance on the quality and quantity of evidence needed to justify conclusions on functional and clinical effects of nutrition in infants and young children aged <3 years; (2) agree on a range of outcome measures relevant to nutrition trials in this age group for which agreed criteria are needed; (3) agree on an updated 'core data set' that should generally be recorded in nutrition trials in infants and young children, and (4) provide guidance on the use of surrogate markers in paediatric nutrition research. The participants discussed these objectives and agreed to set up six first working groups under the auspices of the Consensus Group on Outcome Measures Made in Paediatric Enteral Nutrition Clinical Trials (COMMENT). Five groups will aim to identify and define criteria for assessing key outcomes, i.e. growth, acute diarrhoea, atopic dermatitis and cows' milk protein allergy, infections and 'gut comfort'. The sixth group will review and update the 'core data set'. The COMMENT Steering Committee will discuss and decide upon a method for reaching consensus which will be used by all working groups and plan to meet again within 2 years and to report and publish their conclusions.

Original languageEnglish
Pages (from-to)222-232
Number of pages11
JournalAnnals of Nutrition and Metabolism
Volume60
Issue number4
DOIs
Publication statusPublished - Jun 1 2012

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Keywords

  • Allergy
  • Clinical trials
  • Consensus Group on Outcome Measures Made in Paediatric Enteral Nutrition Clinical Trials
  • Core data
  • Diarrhoea
  • Early Nutrition Academy
  • European Society for Paediatric Gastroenterology, Hepatology and Nutrition
  • Functional effects
  • Growth
  • Infants
  • Markers
  • Nutritional interventions
  • Outcome measures
  • Young children

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Koletzko, B., Szajewska, H., Ashwell, M., Shamir, R., Aggett, P., Baerlocher, K., Noakes, P., Braegger, C., Calder, P., Campoy Folgoso, C., Colomb, V., Decsi, T., Domellöf, M., Dupont, C., Fewtrell, M., Van Goudoever, J. B., Michaelsen, K. F., Mihatsch, W., Guarino, A., ... Taminiau, J. (2012). Documentation of functional and clinical effects of infant nutrition: Setting the scene for COMMENT. Annals of Nutrition and Metabolism, 60(4), 222-232. https://doi.org/10.1159/000337681