Gene expression is directly regulated by nuclear transcription factors (TFs), which exert their regulatory effects through their binding to specific TF binding sites (TFBS) on the promoter sequences of target genes. We analyzed the presence of TFBS in promoter sequences of the members of published gene lists containing highly expressed or decreased genes associated with endometriosis (EM). A total number of 339 genes with altered expression in EM were reported in 4 studies. Promoter sequences were available for 135 genes. TFBSs on promoter sequences (1 kb upstream and 0.05 kb downstream of the transcriptional start sites) were identified and prevalence was compared to the human background model derived from the eukaryotic promoter database. The investigated promoter sequences contained TFBSs for 235 different genes, The prevalence of Sp1 and GC-rich was higher (p<0.005) in the promoter sequences as compared to the background model. Our results suggest the possible contribution of Sp1 to the specific gene expression profile observed in EM. The generated hypotheses suggest new targets for research and, possibly, drug development.
|Number of pages||4|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jun 14 2007|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology