Do testicular opiates regulate Leydig cell function?

I. Gerendai, C. Shaha, R. Thau, C. W. Bardin

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

β-Endorphin is believed to be synthesized in testicular Leydig cells. To gain more information about the role of this and other endogenous opioid peptides in the testis, opiate antagonists (naloxone and nalmefene, 100 μg/testis) were administered intratesticularly to hemicastrated adult rats. Leydig cell function was evaluated by measurement of serum testosterone and testosterone production in vitro. Estimation of androgen binding protein (rABP) was used as an index of Sertoli cell function. Serum testosterone was reduced significantly by intratesticular administration of naloxone and nalmefene in treated animals. Systemic administration of these antagonists had no effect at the doses used. Testes from treated animals incubated in vitro with or without hCG produced significantly less testosterone than vehicle-treated control testes. Hemicastration reduced rABP synthesis and secretion; however, treatment with opiate antagonists did not alter the amount of this protein in the serum or epididymides of these rats. These observations suggest that endogenous testicular opiates modulate testosterone secretion by Leydig cells.

Original languageEnglish
Pages (from-to)1645-1647
Number of pages3
JournalEndocrinology
Volume115
Issue number4
Publication statusPublished - 1984

Fingerprint

Opiate Alkaloids
Leydig Cells
Testosterone
Testis
Opioid Peptides
Naloxone
Androgen-Binding Protein
Endorphins
Sertoli Cells
Epididymis
Serum
Blood Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Gerendai, I., Shaha, C., Thau, R., & Bardin, C. W. (1984). Do testicular opiates regulate Leydig cell function? Endocrinology, 115(4), 1645-1647.

Do testicular opiates regulate Leydig cell function? / Gerendai, I.; Shaha, C.; Thau, R.; Bardin, C. W.

In: Endocrinology, Vol. 115, No. 4, 1984, p. 1645-1647.

Research output: Contribution to journalArticle

Gerendai, I, Shaha, C, Thau, R & Bardin, CW 1984, 'Do testicular opiates regulate Leydig cell function?', Endocrinology, vol. 115, no. 4, pp. 1645-1647.
Gerendai I, Shaha C, Thau R, Bardin CW. Do testicular opiates regulate Leydig cell function? Endocrinology. 1984;115(4):1645-1647.
Gerendai, I. ; Shaha, C. ; Thau, R. ; Bardin, C. W. / Do testicular opiates regulate Leydig cell function?. In: Endocrinology. 1984 ; Vol. 115, No. 4. pp. 1645-1647.
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