Do guidelines for the diagnosis and monitoring of diabetes mellitus fulfill the criteria of evidence-based guideline development?

Eva Nagy, Joseph Watine, Peter S. Bunting, Rita Onody, Wytze P. Oosterhuis, Dunja Rogic, Sverre Sandberg, Krisztina Boda, Andrea R. Horvath

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

BACKGROUND: Although the methodological quality of therapeutic guidelines (GLs) has been criticized, little is known regarding the quality of GLs that make diagnostic recommendations. Therefore, we assessed the methodological quality of GLs providing diagnostic recommendations for managing diabetes mellitus (DM) and explored several reasons for differences in quality across these GLs. METHODS: After systematic searches of published and electronic resources dated between 1999 and 2007, 26 DM GLs, published in English, were selected and scored for methodological quality using the AGREE Instrument. Subgroup analyses were performed based on the source, scope, length, origin, and date and type of publication of GLs. Using a checklist, we collected laboratory-specific items within GLs thought to be important for interpretation of test results. RESULTS: The 26 diagnostic GLs had significant short-comings in methodological quality according to the AGREE criteria. GLs from agencies that had clear procedures for GL development, were longer than 50 pages, or were published in electronic databases were of higher quality. Diagnostic GLs contained more preanalytical or analytical information than combined (i.e., diagnostic and therapeutic) recommendations, but the overall quality was not significantly different. The quality of GLs did not show much improvement over the time period investigated. CONCLUSIONS: The methodological shortcomings of diagnostic GLs in DM raise questions regarding the validity of recommendations in these documents that may affect their implementation in practice. Our results suggest the need for standardization of GL terminology and for higher-quality, systematically developed recommendations based on explicit guideline development and reporting standards in laboratory medicine.

Original languageEnglish
Pages (from-to)1872-1882
Number of pages11
JournalClinical chemistry
Volume54
Issue number11
DOIs
Publication statusPublished - Nov 1 2008

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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    Nagy, E., Watine, J., Bunting, P. S., Onody, R., Oosterhuis, W. P., Rogic, D., Sandberg, S., Boda, K., & Horvath, A. R. (2008). Do guidelines for the diagnosis and monitoring of diabetes mellitus fulfill the criteria of evidence-based guideline development? Clinical chemistry, 54(11), 1872-1882. https://doi.org/10.1373/clinchem.2008.109082