Do alpha-2 adrenoceptors modify coping strategies in rats?

J. Haller, D. T. Kiem, G. Makara

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Previous research has shown that resident rats treated with α2 adrenoceptor blockers display a modified aggressive response towards intruding animals. In the present study we report data on the behavioral changes induced by α2 adrenoceptor blockers in intruder animals. In experiments 1 and 2 intruders smaller in body weight than the residents were treated with 0.0, 0.5, and 1.0 mg/kg CH-38083 and idazoxan, respectively; in experiment 3 weight matched intruders were injected with 1 mg/kg CH-38083 or idazoxan. The treatment of smaller intruders did not change the behavior of residents. In contrast, weight-matched intruders injected with α2 adrenoceptor blockers elicited increased aggression in residents. Social behaviors, exploration and offensive aggression showed insignificant variation in intruders. Defensive behaviors, in contrast, showed major changes: in experiments 1 and 2 a dose-dependent decrease in immobility and a dose-dependent increase in defensive upright was noticed. In experiment 3, high scores of defensive upright were apparent, precluding detection of drug-induced changes. However, when the last 5 min of the encounter were analysed separately, results similar to the first two experiments were observed. Significant negative correlations were found between immobility and defensive upright scores. The results suggest that α2 adrenoceptor blockers induce a shift from a passive (immobility) towards a more active (defensive upright) coping style. These and previous data show that α2 adrenoceptor blockers, other than yohimbine, seem to exert a behavior-activating effect in rats.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalPsychopharmacology
Volume122
Issue number4
DOIs
Publication statusPublished - Dec 1995

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Adrenergic Receptors
Idazoxan
Aggression
Weights and Measures
Yohimbine
Social Behavior
Body Weight
Research
Pharmaceutical Preparations
7,8-(methylenedioxy)-14-hydroxyberbane

Keywords

  • α Adrenoceptors
  • Aggression
  • Catecholamines
  • CH-38083
  • Coping
  • Idazoxan
  • Rats

ASJC Scopus subject areas

  • Pharmacology

Cite this

Do alpha-2 adrenoceptors modify coping strategies in rats? / Haller, J.; Kiem, D. T.; Makara, G.

In: Psychopharmacology, Vol. 122, No. 4, 12.1995, p. 379-385.

Research output: Contribution to journalArticle

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