DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia

An association study

Sibylle G. Schwab, Christie Plummer, Margot Albus, Margitta Borrmann-Hassenbach, Bernard Lerer, M. Trixler, Wolfgang Maier, Dieter B. Wildenauer

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

OBJECTIVES: Recent studies investigating the association of DNA variants in the metabotropic glutamate receptor gene (GRM3) with schizophrenia susceptibility revealed conflicting results. In this study, we focused on DNA sequence variants, for which association was reported and attempted to replicate association with schizophrenia or with cognitive deficits known to be present in patients with schizophrenia. METHODS: A sample of 242 families with affected offspring and five single nucleotide markers located in the genomic region of GRM3 has been used to replicate association with schizophrenia. In addition, results of neuropsychological tests, trail making test B and the Stroop color-naming task were available for a subgroup of these families (N=88) and an independent sample of 148 patients with schizophrenia. Correlation of these measurements with genotypic data was performed using analysis of variance. RESULTS: No statistical evidence for association with schizophrenia or correlation with cognitive deficits as measured by the trail making test B or the Stroop color-naming task and the five DNA sequence variants could be detected. A trend towards association with schizophrenia was revealed for a single marker (rs2237562, P=0.056) and for 2-marker and 3-marker haplotypes containing this variant. CONCLUSIONS: Our study of DNA sequence variants in the GRM3 gene did not provide further support for genetic association with schizophrenia or for correlation with cognitive deficits.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalPsychiatric Genetics
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Schizophrenia
Trail Making Test
Color
Metabotropic Glutamate Receptors
metabotropic glutamate receptor 3
Neuropsychological Tests
Haplotypes
Genes
Analysis of Variance
Nucleotides
DNA

Keywords

  • Cognitive deficits
  • Family based association analysis
  • Metabotropic glutamate receptor 3
  • Schizophrenia
  • Stroop color-naming test
  • Trail making test B

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Cite this

DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia : An association study. / Schwab, Sibylle G.; Plummer, Christie; Albus, Margot; Borrmann-Hassenbach, Margitta; Lerer, Bernard; Trixler, M.; Maier, Wolfgang; Wildenauer, Dieter B.

In: Psychiatric Genetics, Vol. 18, No. 1, 02.2008, p. 25-30.

Research output: Contribution to journalArticle

Schwab, SG, Plummer, C, Albus, M, Borrmann-Hassenbach, M, Lerer, B, Trixler, M, Maier, W & Wildenauer, DB 2008, 'DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: An association study', Psychiatric Genetics, vol. 18, no. 1, pp. 25-30. https://doi.org/10.1097/YPG.0b013e3282ef48d9
Schwab, Sibylle G. ; Plummer, Christie ; Albus, Margot ; Borrmann-Hassenbach, Margitta ; Lerer, Bernard ; Trixler, M. ; Maier, Wolfgang ; Wildenauer, Dieter B. / DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia : An association study. In: Psychiatric Genetics. 2008 ; Vol. 18, No. 1. pp. 25-30.
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