DNA content of parathyroid tumors

Jozsef Bocsi, Ferenc Perner, Janos Szücs, Edit Glaz, Laszlo Kopper

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The significance of DNA ploidy in indicating the benign or malignant character of parathyroid and other endocrin tumors is controversial. Materials and methods: DNA content of paraffin embedded parathyroid samples from 25 patients was measured with flow cytometry. Results: The DNA index (DI) was 1.0 in all nonneoplastic samples as well as in 50% of adenomas (10/20) and in one carcinoma (1/2). The remaining 45% of the adenoma cases (9/20) and the other carcinoma showed doubled DNA content (DI = 1.9-2.0). The increased DI did not correlate with either clinical data (sex, age, tumor size, preoperative serum Ca++ or parathormone, primary or secondary hyperparathyreoidism) or morphology. Conclusions: These results indicate that the DI has no value in deciding the benign or malignant character of a given sample. However, the prognostic value of tetraploidization (the potentially increased risk for malignancy) could not be ruled out.

Original languageEnglish
Pages (from-to)2901-2904
Number of pages4
JournalAnticancer research
Volume18
Issue number4 B
Publication statusPublished - Jul 1 1998

Keywords

  • DNA content
  • Flow cytometry
  • Parathyroid
  • Tumors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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