DNA content of parathyroid tumors

Jozsef Bocsi, F. Perner, Janos Szücs, E. Gláz, L. Kópper

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The significance of DNA ploidy in indicating the benign or malignant character of parathyroid and other endocrin tumors is controversial. Materials and methods: DNA content of paraffin embedded parathyroid samples from 25 patients was measured with flow cytometry. Results: The DNA index (DI) was 1.0 in all nonneoplastic samples as well as in 50% of adenomas (10/20) and in one carcinoma (1/2). The remaining 45% of the adenoma cases (9/20) and the other carcinoma showed doubled DNA content (DI = 1.9-2.0). The increased DI did not correlate with either clinical data (sex, age, tumor size, preoperative serum Ca++ or parathormone, primary or secondary hyperparathyreoidism) or morphology. Conclusions: These results indicate that the DI has no value in deciding the benign or malignant character of a given sample. However, the prognostic value of tetraploidization (the potentially increased risk for malignancy) could not be ruled out.

Original languageEnglish
Pages (from-to)2901-2904
Number of pages4
JournalAnticancer Research
Volume18
Issue number4 B
Publication statusPublished - Jul 1998

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DNA
Neoplasms
Adenoma
Carcinoma
Ploidies
Parathyroid Hormone
Paraffin
Flow Cytometry
Serum

Keywords

  • DNA content
  • Flow cytometry
  • Parathyroid
  • Tumors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

DNA content of parathyroid tumors. / Bocsi, Jozsef; Perner, F.; Szücs, Janos; Gláz, E.; Kópper, L.

In: Anticancer Research, Vol. 18, No. 4 B, 07.1998, p. 2901-2904.

Research output: Contribution to journalArticle

Bocsi, J, Perner, F, Szücs, J, Gláz, E & Kópper, L 1998, 'DNA content of parathyroid tumors', Anticancer Research, vol. 18, no. 4 B, pp. 2901-2904.
Bocsi, Jozsef ; Perner, F. ; Szücs, Janos ; Gláz, E. ; Kópper, L. / DNA content of parathyroid tumors. In: Anticancer Research. 1998 ; Vol. 18, No. 4 B. pp. 2901-2904.
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