DNA adduct formation in human and mouse skin by mixtures of polycyclic aromatic hydrocarbons.

D. H. Phillips, B. Schoket, A. Hewer, P. L. Grover

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

32P-Postlabelling analysis has been used to detect the formation in vivo of DNA adducts by components of complex mixtures of polycyclic aromatic hydrocarbons (PAHs) in coal-tar, creosote, bitumen, juniper tar, used engine oils and fuel exhaust condensates. The presence of DNA adducts derived from these agents has been investigated in mouse skin, in human skin explants maintained in short-term organ culture and in human skin in vivo, and the formation of many different PAH-DNA adducts was observed. Similar levels and patterns of adducts were found in DNA from human skin to those in mouse skin, which is known to be susceptible to the carcinogenic activity of PAH mixtures, thus demonstrating the potential hazard to man of epidermal contact with these materials.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalIARC scientific publications
Issue number104
Publication statusPublished - 1990

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DNA Adducts
Polycyclic Aromatic Hydrocarbons
Skin
asphalt
Creosote
Coal Tar
Organ Culture Techniques
Complex Mixtures
Oils
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

DNA adduct formation in human and mouse skin by mixtures of polycyclic aromatic hydrocarbons. / Phillips, D. H.; Schoket, B.; Hewer, A.; Grover, P. L.

In: IARC scientific publications, No. 104, 1990, p. 223-229.

Research output: Contribution to journalArticle

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