DMBA induces deregulation of miRNA expression of let-7, miR-21 and miR-146a in CBA/CA mice

Krisztina Juhász, Katalin Gombos, Mónika Szirmai, Péter Révész, Ingrid Magda, Katalin Göcze, István Ember

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7 Citations (Scopus)

Abstract

Background: 7, 12-Dimethylbenz(α)anthracene (DMBA) is a carcinogen capable of inducing various types of tumors. Materials and Methods: We investigated the effect of DMBA on micro-RNA expression in CBA/CA H2 k inbred mice after 24 hours and one week from exposure. Results: Expression levels of miR-21, miR-146a and let-7a were significantly higher in the vital organs of the mice 24 hours after DMBA exposure compared to those of the controls. On the other hand, a significant down-regulation of the miRNAs was observed seven days after DMBA administration. Conclusion: Based on our data, DMBA has an impact on the expression of miR-21, let-7a and miR-146a genes. The altered micro-RNA expression can be regarded as an early effect of exposure to chemical carcinogens. To our knowledge, this is the first study of miRNA modulation caused by DMBA in non-malignant tissues.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalIn Vivo
Volume26
Issue number1
Publication statusPublished - Jan 1 2012

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Keywords

  • 7,12-Dimethylbenz(α)anthracene
  • Let-7a
  • miR-146a
  • miR-21
  • miRNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Juhász, K., Gombos, K., Szirmai, M., Révész, P., Magda, I., Göcze, K., & Ember, I. (2012). DMBA induces deregulation of miRNA expression of let-7, miR-21 and miR-146a in CBA/CA mice. In Vivo, 26(1), 113-117.