Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade

Katharina Schulenburg, Gabor Glatz, A. Reményi, Krishnaraj Rajalingam

Research output: Contribution to journalArticle

Abstract

Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results reveal another layer of MAPK regulation and a novel role for XIAP in controlling myogenic differentiation.

Original languageEnglish
Article numbere969170
JournalMolecular and Cellular Oncology
Volume1
Issue number4
DOIs
Publication statusPublished - Dec 8 2014

Keywords

  • cIAP1
  • ERK5
  • IAP
  • MAPK
  • PB1
  • ubiquitin
  • XIAP

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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