Diversity Profile and Dynamics of Peptaibols Produced by Green Mould Trichoderma Species in Interactions with Their Hosts Agaricus bisporus and Pleurotus ostreatus

Tamás Marik, Péter Urbán, Chetna Tyagi, A. Szekeres, Balázs Leitgeb, Máté Vágvölgyi, L. Manczinger, Irina S. Druzhinina, C. Vágvölgyi, L. Kredics

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Certain Trichoderma species are causing serious losses in mushroom production worldwide. Trichoderma aggressivum and Trichoderma pleuroti are among the major causal agents of the green mould diseases affecting Agaricus bisporus and Pleurotus ostreatus, respectively. The genus Trichoderma is well-known for the production of bioactive secondary metabolites, including peptaibols, which are short, linear peptides containing unusual amino acid residues and being synthesised via non-ribosomal peptide synthetases (NRPSs). The aim of this study was to get more insight into the peptaibol production of T. aggressivum and T. pleuroti. HPLC/MS-based methods revealed the production of peptaibols closely related to hypomurocins B by T. aggressivum, while tripleurins representing a new group of 18-residue peptaibols were identified in T. pleuroti. Putative NRPS genes enabling the biosynthesis of the detected peptaibols could be found in the genomes of both Trichoderma species. In vitro experiments revealed that peptaibols are potential growth inhibitors of mushroom mycelia, and that the host mushrooms may have an influence on the peptaibol profiles of green mould agents.

Original languageEnglish
Article numbere1700033
JournalChemistry and Biodiversity
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

Keywords

  • Cultivated mushrooms
  • Liquid chromatography
  • Mass spectrometry
  • Peptaibol
  • Trichoderma green mould

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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