Diverse origin of P[19] rotaviruses in children with acute diarrhea in Taiwan

Detection of novel lineages of the G3, G5, and G9 VP7 genes

Fang Tzy Wu, K. Bányai, Jason C. Huang, Ho Sheng Wu, Feng Yee Chang, Jyh Yuan Yang, Chao Agnes Hsiung, Yhu Chering Huang, Jen Shiou Lin, Kao Pin Hwang, Baoming Jiang, Jon R. Gentsch

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We previously reported the detection of genotype P[19] rotavirus strains from children hospitalized with acute dehydrating diarrhea during a 5-year surveillance period in Taiwan. The characterization of five P[19] strains (0.4% of all typed), including three G3P[19], a novel G5P[19], and a unique G9P[19] genotype is described in this study. Phylogenetic analysis of the VP4, VP7, VP6, and NSP4 genes was performed, which demonstrated novel lineages for respective genotypes of the VP4 and the VP7 genes. The sequence similarities of the P[19] VP4 gene among Taiwanese human strains was higher (nt, 91.5-96.2%; aa, 93.7-97.6%) than to other P[19] strains (nt, 83.5-86.6%; aa, 89.4-94.1%) from different regions of the world. The VP7 gene of the three G3P[19] Taiwanese strains shared up to 93.4% nt and 97.5% aa identity to each other but had lower similarity to reference strain sequences available in GenBank (nt,

Original languageEnglish
Pages (from-to)1279-1287
Number of pages9
JournalJournal of Medical Virology
Volume83
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Rotavirus
Taiwan
Diarrhea
Genotype
Genes
Hospitalized Child
Nucleic Acid Databases

Keywords

  • NSP4
  • Phylogenetic analysis
  • VP4
  • VP6
  • VP7

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Diverse origin of P[19] rotaviruses in children with acute diarrhea in Taiwan : Detection of novel lineages of the G3, G5, and G9 VP7 genes. / Wu, Fang Tzy; Bányai, K.; Huang, Jason C.; Wu, Ho Sheng; Chang, Feng Yee; Yang, Jyh Yuan; Hsiung, Chao Agnes; Huang, Yhu Chering; Lin, Jen Shiou; Hwang, Kao Pin; Jiang, Baoming; Gentsch, Jon R.

In: Journal of Medical Virology, Vol. 83, No. 7, 07.2011, p. 1279-1287.

Research output: Contribution to journalArticle

Wu, FT, Bányai, K, Huang, JC, Wu, HS, Chang, FY, Yang, JY, Hsiung, CA, Huang, YC, Lin, JS, Hwang, KP, Jiang, B & Gentsch, JR 2011, 'Diverse origin of P[19] rotaviruses in children with acute diarrhea in Taiwan: Detection of novel lineages of the G3, G5, and G9 VP7 genes', Journal of Medical Virology, vol. 83, no. 7, pp. 1279-1287. https://doi.org/10.1002/jmv.22052
Wu, Fang Tzy ; Bányai, K. ; Huang, Jason C. ; Wu, Ho Sheng ; Chang, Feng Yee ; Yang, Jyh Yuan ; Hsiung, Chao Agnes ; Huang, Yhu Chering ; Lin, Jen Shiou ; Hwang, Kao Pin ; Jiang, Baoming ; Gentsch, Jon R. / Diverse origin of P[19] rotaviruses in children with acute diarrhea in Taiwan : Detection of novel lineages of the G3, G5, and G9 VP7 genes. In: Journal of Medical Virology. 2011 ; Vol. 83, No. 7. pp. 1279-1287.
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