Diverse mutagenicity of methylbenz[c]acridines in the direct Ames' salmonella mutagenicity assay

Masaru Tanaka, Klara Csuri, Joseph Molnar, Noboru Motohashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The mutagenicity of eleven methylbenz[c]acridines (methyl-B[c]ACRs] was examined by the direct Ames' Salmonella mutagenicity assay on the standard tester strains of TA97a, TA98, TA100 and TA102, each of which is specific to a certain type of mutation. The Benz[c]acridines (B[c]ACRs) studied in this investigation were substituted with one to three methyl group(s) at the 5, 7, 8, 9, 10 and 11 position(s) of B[c]ACR. A certain degree of mutagenic activity was observed by all methyl-B[c]ACRs on at least one of the tester strains, indicating that even non-carcinogenic methyl-B[c]ACRs showed mutagenicity in the assay. Meanwhile, 7,10-dimethyl-B[c]ACR and 7,9,10-trimethyl-B[c]ACR significantly increased the number of back-mutant colonies. However, monomethyl-B[c]ACRs, 7-methyl-B[c]ACR and 10-methyl-B[c]ACR did not increase back-mutation except for TA102 and TA100, respectively. The induction of 7-methyl substituent on B[c]ACR appears to play a key role in frameshift (+1 and -1), base-pair substitution, and single base substitution mutation of the strains in the presence of additional methyl substituent(s) at C-9 and/or C-10 posltion(s) of D ring of B[c]ACR.

Original languageEnglish
Pages (from-to)2837-2841
Number of pages5
JournalAnticancer research
Volume16
Issue number5 A
Publication statusPublished - Sep 1 1996

Keywords

  • Ames' test
  • Benz[c]acridines
  • Mutagenicity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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