Diverse expression of the K-1 antigen by cortico-medullary and reticular epithelial cells of the bursa of Fabricius in chicken and guinea fowl

I. Oláh, K. H. Gumati, N. Nagy, A. Magyar, B. Kaspers, H. Lillehoj

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The immunocytochemical study of the K-1 monoclonal antibody indicates that the epithelial components of the bursa of Fabricius of the chicken and guinea fowl express the K-1 positive molecule. During embryogenesis, the K-1 antigen expression appears together with the bud-formation. As the number of B cells increases in the developing follicle, the K-1 expression gradually diminishes in the medullary reticular epithelial cells and completely ceases by hatching, which suggests that the molecule is developmentally regulated. After hatching, the expression of the molecule is restricted to the sealing off zone of the lymphoepithelial or medullary region of the follicle: i.e. to the cortico-medullary (CM) epithelial cells and the follicle associated epithelium (FAE) supporting cells in guinea fowl and to the latter ones in the chicken. The expression of the K-1 antigen by these epithelial components may support their structural identity. After hatching, the K-1 molecule is restricted to the CM epithelial cells and/or FAE supporting cells, which suggests that the function of the embryonic epithelial bud is taken over by the CM epithelial cells. The K-1 positive CM epithelial cells form arches, which encompass blast-like cells. The possible relationship of the CM epithelial cells and blast-like cells, which may represent the precursors of bursal secretory dendritic cells is discussed.

Original languageEnglish
Pages (from-to)481-488
Number of pages8
JournalDevelopmental and Comparative Immunology
Volume26
Issue number5
DOIs
Publication statusPublished - 2002

Fingerprint

Bursa of Fabricius
Guinea
Chickens
Epithelial Cells
Epithelium
Dendritic Cells
Embryonic Development
K antigens
B-Lymphocytes
Monoclonal Antibodies

Keywords

  • Bursa of Fabricius
  • Chicken
  • Cortico-medullary epithelium
  • Developmentally regulated K-1 expression
  • Guinea fowl
  • Immunocytochemistry
  • K-1 monoclonal antibody
  • Precursor of secretory dendritic cell

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology

Cite this

Diverse expression of the K-1 antigen by cortico-medullary and reticular epithelial cells of the bursa of Fabricius in chicken and guinea fowl. / Oláh, I.; Gumati, K. H.; Nagy, N.; Magyar, A.; Kaspers, B.; Lillehoj, H.

In: Developmental and Comparative Immunology, Vol. 26, No. 5, 2002, p. 481-488.

Research output: Contribution to journalArticle

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