Diurnal variation in fentanyl-induced hormone responses and side effects

Ede Frecska, Mihaly Arato, Csaba M. Banki, Gyorgy Bagdy, Andras Perenyi, Katalin Mohari, Marion I.K. Fekete

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The prolactin (PRL) and thyrotropin (TSH) secretory response to the opioid agonist fentanyl (0.1 mg IV) was investigated with serial blood sampling in ten healthy women at 9 am and 9 pm on different days. In five subjects saline control trials were also performed. A repeated-measures analysis of variance yielded a highly significant effect of fentanyl administration both on PRL and TSH secretion. In every case there were elevated hormone responses in the evening, and more drug-related subjective symptoms were reported at this time than before noon. These findings indicate a diurnal variation of opioid responsiveness, with lower sensitivity in the morning.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalNeuropsychopharmacology
Volume1
Issue number3
DOIs
Publication statusPublished - Sep 1988

    Fingerprint

Keywords

  • Chronobiology
  • Circadian Rhythm
  • Endocrinology
  • Narcotics
  • Prolactin
  • Thyrotropin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this