Diurnal variation in fentanyl-induced hormone responses and side effects

Ede Frecska, Mihaly Arato, Csaba M. Banki, Gyorgy Bagdy, Andras Perenyi, Katalin Mohari, Marion I.K. Fekete

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3 Citations (Scopus)


The prolactin (PRL) and thyrotropin (TSH) secretory response to the opioid agonist fentanyl (0.1 mg IV) was investigated with serial blood sampling in ten healthy women at 9 am and 9 pm on different days. In five subjects saline control trials were also performed. A repeated-measures analysis of variance yielded a highly significant effect of fentanyl administration both on PRL and TSH secretion. In every case there were elevated hormone responses in the evening, and more drug-related subjective symptoms were reported at this time than before noon. These findings indicate a diurnal variation of opioid responsiveness, with lower sensitivity in the morning.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
Issue number3
Publication statusPublished - Sep 1988



  • Chronobiology
  • Circadian Rhythm
  • Endocrinology
  • Narcotics
  • Prolactin
  • Thyrotropin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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