Diurnal changes in hypothalamic serotonin content and its correlation with adrenal function in the rat during the oestrus cycle

G. Rozsahegyi, G. Telegdy, K. Lissak

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Abstract

Hypothalamic serotonin content and plasma corticosterone level were measured daily at 8 a.m., 4 p.m., and 11 p.m., during different phases of the estrus cycle in rats. The hypothalamic serotonin level showed a diurnal variation with a peak at 8 a.m. and the lowest level at 11 p.m. The morning level during proestrus and estrus was significantly lower than in metestrus and diestrus. The decrease in the hypothalamic serotonin level observed at 11 p.m. was significant in each phase of the cycle but it was the most marked during proestrus. The plasma corticosterone level showed an opposite trend. It was low in the morning and high at 11 p.m. in each phase of the estrus cycle except during estrus when there was no significant difference between the morning and the late evening value. The morning values in proestrus and estrus were twice as high as those in the metestrus and diestrus phases. Ovariectomy did not abolish the daily serotonin rhythm in the hypothalamus, but the morning value was significantly lower than in the proestrus, metestrus and diestrus phases. Estrone and progesterone treatment increased the morning hypothalamic serotonin level of castrated famale rats.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume44
Issue number2
Publication statusPublished - 1974

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Estrus
Proestrus
Metestrus
Serotonin
Diestrus
Corticosterone
Estrone
Ovariectomy
Hypothalamus
Progesterone

ASJC Scopus subject areas

  • Physiology

Cite this

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title = "Diurnal changes in hypothalamic serotonin content and its correlation with adrenal function in the rat during the oestrus cycle",
abstract = "Hypothalamic serotonin content and plasma corticosterone level were measured daily at 8 a.m., 4 p.m., and 11 p.m., during different phases of the estrus cycle in rats. The hypothalamic serotonin level showed a diurnal variation with a peak at 8 a.m. and the lowest level at 11 p.m. The morning level during proestrus and estrus was significantly lower than in metestrus and diestrus. The decrease in the hypothalamic serotonin level observed at 11 p.m. was significant in each phase of the cycle but it was the most marked during proestrus. The plasma corticosterone level showed an opposite trend. It was low in the morning and high at 11 p.m. in each phase of the estrus cycle except during estrus when there was no significant difference between the morning and the late evening value. The morning values in proestrus and estrus were twice as high as those in the metestrus and diestrus phases. Ovariectomy did not abolish the daily serotonin rhythm in the hypothalamus, but the morning value was significantly lower than in the proestrus, metestrus and diestrus phases. Estrone and progesterone treatment increased the morning hypothalamic serotonin level of castrated famale rats.",
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T1 - Diurnal changes in hypothalamic serotonin content and its correlation with adrenal function in the rat during the oestrus cycle

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AU - Telegdy, G.

AU - Lissak, K.

PY - 1974

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N2 - Hypothalamic serotonin content and plasma corticosterone level were measured daily at 8 a.m., 4 p.m., and 11 p.m., during different phases of the estrus cycle in rats. The hypothalamic serotonin level showed a diurnal variation with a peak at 8 a.m. and the lowest level at 11 p.m. The morning level during proestrus and estrus was significantly lower than in metestrus and diestrus. The decrease in the hypothalamic serotonin level observed at 11 p.m. was significant in each phase of the cycle but it was the most marked during proestrus. The plasma corticosterone level showed an opposite trend. It was low in the morning and high at 11 p.m. in each phase of the estrus cycle except during estrus when there was no significant difference between the morning and the late evening value. The morning values in proestrus and estrus were twice as high as those in the metestrus and diestrus phases. Ovariectomy did not abolish the daily serotonin rhythm in the hypothalamus, but the morning value was significantly lower than in the proestrus, metestrus and diestrus phases. Estrone and progesterone treatment increased the morning hypothalamic serotonin level of castrated famale rats.

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