Diurnal blood pressure pattern may predict the increase of urinary albumin excretion in normotensive normoalbuminuric type 1 diabetes mellitus patients

Zoltán Lengyel, L. Rosivall, Csilla Németh, Lajos K. Tóth, Viktor Nagy, Mária Mihály, László Kammerer, Péter Vörös

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To characterise the relationship between diurnal blood pressure and the subsequent increase of urinary albumin excretion (UAE) in normotensive normoalbuminuric type 1 diabetic patients, ambulatory blood pressure monitoring (ABPM) was performed in 53 patients, who were then followed for 5 years. Albumin excretion rate changed from 12.4 (8.9-17.2) to 29.3 (15.2-47.0) mg/day. Macroalbuminuria developed in 2 (3.8%), microalbuminuria in 22 (41.5%) patients, 29 (54.7%) remained normoalbuminuric. Night-time diastolic blood pressure was significantly higher (64.3±6.5 vs. 60.9±5.5 mmHg, P1c and retinopathy as independent parameters (r=0.68; P=0.001), diurnal index for diastolic blood pressure (β=-0.30; r=0.013), baseline HbA1c (β=0.32; P=0.010) and retinopathy (β=0.44; P=0.001) were significant independent correlates. We conclude that the relative increase of nocturnal blood pressure is associated with the subsequent increase of albuminuria, which in turn is predictive of overt diabetic nephropathy.

Original languageEnglish
Pages (from-to)159-167
Number of pages9
JournalDiabetes Research and Clinical Practice
Volume62
Issue number3
DOIs
Publication statusPublished - Dec 2003

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Type 1 Diabetes Mellitus
Albumins
Blood Pressure
Ambulatory Blood Pressure Monitoring
Albuminuria
Diabetic Nephropathies

Keywords

  • Blood pressure
  • Diabetes
  • Diurnal variation
  • Microalbuminuria
  • Nephropathy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Diurnal blood pressure pattern may predict the increase of urinary albumin excretion in normotensive normoalbuminuric type 1 diabetes mellitus patients. / Lengyel, Zoltán; Rosivall, L.; Németh, Csilla; Tóth, Lajos K.; Nagy, Viktor; Mihály, Mária; Kammerer, László; Vörös, Péter.

In: Diabetes Research and Clinical Practice, Vol. 62, No. 3, 12.2003, p. 159-167.

Research output: Contribution to journalArticle

Lengyel, Zoltán ; Rosivall, L. ; Németh, Csilla ; Tóth, Lajos K. ; Nagy, Viktor ; Mihály, Mária ; Kammerer, László ; Vörös, Péter. / Diurnal blood pressure pattern may predict the increase of urinary albumin excretion in normotensive normoalbuminuric type 1 diabetes mellitus patients. In: Diabetes Research and Clinical Practice. 2003 ; Vol. 62, No. 3. pp. 159-167.
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