Dithranol-induced down-regulation of 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE] receptors in a human epidermal cell line

L. Kemény, E. Gross, P. Arenberger, T. Ruzicka

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of dithranol and its therapeutically inactive oxidation product, danthrone, on 12(S)-HETE binding to the human epidermal cell line SCL-II were studied. Dithranol (0.25-1 Μg/ml), in contrast to danthrone, induced a substantial decrease in 12(S)-HETE binding in a dose-dependent manner. The inhibition occurred after a latency period of 6 h, reached its maximum at 18-24 h and slowly declined thereafter. At a concentration of 1 Μg/ ml, the drug led to an approximately 50% decrease in the number of specific high-affinity 12(S)-HEFE receptors (Bmax), whereas receptor affinity (Kd) showed no change. The down-regulation of 12(S)-HETE receptors on epidermal cells by dithranol may contribute to its antipsoriatic action.

Original languageEnglish
Pages (from-to)333-336
Number of pages4
JournalArchives of Dermatological Research
Volume283
Issue number5
DOIs
Publication statusPublished - Jul 1991

Fingerprint

Anthralin
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Down-Regulation
Cell Line
Pharmaceutical Preparations
12-hydroxyeicosatetraenoic acid receptor
danthron

Keywords

  • Dithranol
  • Down-regulation
  • Epidermal 12-HETE receptors

ASJC Scopus subject areas

  • Dermatology

Cite this

Dithranol-induced down-regulation of 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE] receptors in a human epidermal cell line. / Kemény, L.; Gross, E.; Arenberger, P.; Ruzicka, T.

In: Archives of Dermatological Research, Vol. 283, No. 5, 07.1991, p. 333-336.

Research output: Contribution to journalArticle

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