Disturbed planum temporale asymmetry in schizophrenia. A quantitative post-mortem study

Peter Falkai, Bernhard Bogerts, Thomas Schneider, Benno Greve, Ute Pfeiffer, Kirsten Pilz, Carmelita Gonsiorzcyk, Catherine Majtenyi, Imre Ovary

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Abstract

The planum temporale of the temporal cortex was investigated post-mortem in 24 schizophrenic patients and 24 age- and sex-matched control subjects. Schizophrenic patients demonstrated a 20% volume reduction of the left planum temporale (p=0.032), whereas on the right side, there was a trend for increase in male schizophrenics (+22%, p=0.17), while in female patients the volume was moderately decreased (-6%, p=0.74). The mean anterior-posterior diameter of the planum temporale was significantly reduced in the left hemisphere (-20%, p=0.008), but unchanged on the right side. The asymmetry coefficients (Galaburda et al. (1987) Neuropsychologia 25, 853-868) for the planum temporale cortex volume (p=0.02) and anterior-posterior diameter (p=0.002) but not for mean area (p=0.61) were significantly different between schizophrenics and control subjects. These data support the idea of disturbed cerebral laterality in schizophrenia. The implications of methodology and patient samples are discussed.

Original languageEnglish
Pages (from-to)161-176
Number of pages16
JournalSchizophrenia Research
Volume14
Issue number2
DOIs
Publication statusPublished - Jan 1995

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Keywords

  • (Schizophrenia)
  • Laterality
  • Planum temporale
  • Post-mortem study

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Falkai, P., Bogerts, B., Schneider, T., Greve, B., Pfeiffer, U., Pilz, K., Gonsiorzcyk, C., Majtenyi, C., & Ovary, I. (1995). Disturbed planum temporale asymmetry in schizophrenia. A quantitative post-mortem study. Schizophrenia Research, 14(2), 161-176. https://doi.org/10.1016/0920-9964(94)00035-7