Disturbed LDL and scavenger receptor functions in monocytes from chronic haemodialysed patients

István Kárpáti, György Paragh, Éva Kovács, Zoltán Balogh, Márton Szabolcs, Jenõ Szabó, György Kakuk, Gabriella Fóris

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background. The most frequent complication in patients with end-stage renal failure on chronic haemodialysis (HD) treatment is atherosclerosis, i.e. the different forms of heart and vascular diseases. The complete disorder of serum lipid and lipoprotein patterns is well demonstrated, whereas our knowledge about the low-density lipoprotein (LDL) and scavenger receptor expression and function are poorly understood. Methods. In our current work, LDL and scavenger receptor expression and functions were simultaneously studied in monocytes obtained from 15 healthy male control subjects and from 11 chronic HD male patients applied with 125I-labelled LDL, isolated from healthy volunteers. To study the scavenger LDL receptors, labelled acetylated LDL (acLDL) was used. Results. LDL binding to the monocytes of the HD-group was found to be decreased in comparison to that of the controls. As a result, the 50 μg LDL protein-induced inhibition of endogenous cholesterol synthesis was also diminished. In contrast, acLDL binding was greatly increased, though it could trigger only a low apoE synthesis. Consequently the number of cholesterol inclusions in monocytes was increased. Conclusions. The disturbed expression and function of LDL and scavenger receptors both may play significant roles in pathogenesis of cardiovascular complications in chronic HD patients. Based on our present results, it can be assumed that dysfunction of scavenger receptors is at the centre of cardiovascular complications of HD patients with renal failure.

Original languageEnglish
Pages (from-to)2664-2668
Number of pages5
JournalNephrology Dialysis Transplantation
Volume14
Issue number11
DOIs
Publication statusPublished - Jan 1 1999

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Keywords

  • Cholesterol synthesis
  • Foam cell
  • Haemodialysis
  • LDL receptor
  • Monocyte
  • Scavenger receptor

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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