Distribution of prostaglandins E and F in different regions of the rat brain

György Cseh, Ilona K. Szabó, Tibor Láng, Miklós Palkovits

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20 Citations (Scopus)


The regional distribution of prostaglandins E and F in 24 different areas of the rat brain was studied. For bioassay the rat uterine horn preparation was used. Prior to bioassay the samples were purified with organic solvents and in some cases by chromatography on silica as well. For measurement of PGF content in certain areas a radioimmunoassay was used. Each region was found to contain prostaglandins but in uneven concentrations. Highest concentration, related to the protein content, was present in the median eminence, 57.6 ng PGE and 34.4 ng PGF per mg protein. Parietal cortex, olfactory tubercle, cerebellar cortex, caudate nucleus, substantia nigra, and paraventricular nucleus are also rich in prostaglandins. Low values were found in frontal cortex, thalamus, and septum. The distribution of prostaglandins throughout the areas examined do not show any direct correlation with that of transmitter substances. The uneven distribution can be attributed to differences in the endogeneous biosynthetic capacity of each region.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalBrain Research Bulletin
Issue number4
Publication statusPublished - Jan 1 1978


  • E and F Bioassay
  • Microdissectionl
  • Prostaglandin
  • Radioimmunoassay
  • Rat brain nuclei

ASJC Scopus subject areas

  • Neuroscience(all)

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