A lymphocyta szubpopulációk és a plasmasejtek megoszlása colitis ulcerosás gyermekek vastagbél-nyálkahártyájában.

Translated title of the contribution: Distribution of lymphocyte subpopulations and plasma cells in the colonic mucosa of children with ulcerative colitis

A. Arató, E. Savilahti, V. M. Tainio

Research output: Contribution to journalArticle

Abstract

The distribution of lymphocyte subpopulations and plasma cells of the colonic and rectal mucosae were studied in eight children with ulcerative colitis and 12 healthy controls. In four patients the examinations were also carried out 3 months after the beginning of treatment. No difference in the number of intraepithelial lymphocytes was found between the patients and controls. The majority of these cells were T-cells, and among them the suppressor/cytotoxic cells were preponderant. In the lamina propria of both untreated and treated patients the numbers of T-cells, helper T-cells, and B-cells were elevated compared to controls. In the patients the number of IgG-containing cells was three times that of the controls; the number of IgE positive cells was also elevated. The numbers of IgA- and IgM-containing cells were not different from that of the controls. The results suggest that in ulcerative colitis the place of primary immunological processes inside the large bowel mucosa is the lamina propria.

Original languageHungarian
Pages (from-to)1913-1918
Number of pages6
JournalOrvosi Hetilap
Volume131
Issue number35
Publication statusPublished - Sep 2 1990

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Lymphocyte Subsets
Plasma Cells
Ulcerative Colitis
Mucous Membrane
T-Lymphocytes
Lymphocyte Count
Helper-Inducer T-Lymphocytes
Immunoglobulin A
Immunoglobulin E
Immunoglobulin M
B-Lymphocytes
Immunoglobulin G

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A lymphocyta szubpopulációk és a plasmasejtek megoszlása colitis ulcerosás gyermekek vastagbél-nyálkahártyájában. / Arató, A.; Savilahti, E.; Tainio, V. M.

In: Orvosi Hetilap, Vol. 131, No. 35, 02.09.1990, p. 1913-1918.

Research output: Contribution to journalArticle

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AB - The distribution of lymphocyte subpopulations and plasma cells of the colonic and rectal mucosae were studied in eight children with ulcerative colitis and 12 healthy controls. In four patients the examinations were also carried out 3 months after the beginning of treatment. No difference in the number of intraepithelial lymphocytes was found between the patients and controls. The majority of these cells were T-cells, and among them the suppressor/cytotoxic cells were preponderant. In the lamina propria of both untreated and treated patients the numbers of T-cells, helper T-cells, and B-cells were elevated compared to controls. In the patients the number of IgG-containing cells was three times that of the controls; the number of IgE positive cells was also elevated. The numbers of IgA- and IgM-containing cells were not different from that of the controls. The results suggest that in ulcerative colitis the place of primary immunological processes inside the large bowel mucosa is the lamina propria.

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