Distribution of glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in the rat brain - II. Mesencephalon, rhombencephalon and spinal cord

F. Hajós, M. Kálmán

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The topographical mapping of glial fibrillary acidic protein (GFAP)-immunoreactivity was performed in coronal serial sections of the rat mesencephalon, rhombencephalon and spinal cord. Relative to a background of poor or moderate overall staining of the mesencephalon, the interpeduncular nucleus, substantia nigra and the periaqueductal grey matter were prominent by their intense GFAP-immunoreactivity. The pons and particularly the medulla contained more GFAP-labelled elements compared with the mesencephalon. The spinal trigeminal nucleus and Rolando substance were distinguished by their intense staining. Large fibre tracts were usually poor in immunoreactive GFAP. In a concluding discussion, findings relevant to the GFAP-mapping of the whole rat CNS are evaluated with regard to possible reasons underlying the observed differential distribution of GFAP-immunoreactivity.

Original languageEnglish
Pages (from-to)164-173
Number of pages10
JournalExperimental brain research
Issue number1
Publication statusPublished - Nov 1 1989



  • Brainstem
  • GFAP
  • Glia
  • Immunocytochemistry
  • Rat
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

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