Distribution of fibronectin and laminin in human liver tumors

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Two extracellular matrix and basement-membrane components, fibronectin (Fn) and laminin, were studied by the indirect immunoperoxidase technique in ten primary human liver cancers. Similar distributions of both Fn and laminin were detected in the well differentiated hepatocellular carcinomas with trabecular and tubular pattern. Two moderately differentiated hepatomas contained Fn only. Neither Fn nor laminin were present, however, in the parenchyma of one poorly differentiated hepatoma. In three cases of cholangiocarcinoma, laminin surrounded the tumorous ducts, while Fn appeared mainly in the reactive connective tissue stroma. The present findings indicate that bile-duct cancers synthesize laminin, and not Fn while differentiated hepatocellular carcinomas produce both Fn and laminin in vivo. The presence of Fn even in moderately differentiated types of liver cancer is in contrast to the findings for carcinomas developing from other organs and it may serve as a marker for primary hepatocellular carcinomas in the differential diagnosis.

Original languageEnglish
Pages (from-to)60-64
Number of pages5
JournalJournal of Cancer Research and Clinical Oncology
Volume109
Issue number1
DOIs
Publication statusPublished - Feb 1985

Fingerprint

Laminin
Fibronectins
Liver
Hepatocellular Carcinoma
Neoplasms
Liver Neoplasms
Bile Duct Neoplasms
Cholangiocarcinoma
Immunoenzyme Techniques
Basement Membrane
Connective Tissue
Extracellular Matrix
Differential Diagnosis
Carcinoma

Keywords

  • Fibronectin
  • Laminin
  • Liver cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Distribution of fibronectin and laminin in human liver tumors. / Szendrői, M.; Lapis, K.

In: Journal of Cancer Research and Clinical Oncology, Vol. 109, No. 1, 02.1985, p. 60-64.

Research output: Contribution to journalArticle

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