Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats

Miklós Palkovits, Tibor Láng, András Patthy, István Elekes

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Concentrations of glutamate and aspartate have been measured in 45 microdissected brain areas and nuclei in rat. Both amino acids are ubiquitously present and distributed unevenly in the central nervous system. Very high glutamate levels were found in the cerebellum and the insular cortex, high levels in neocortical and limbic cortical areas, and in the nuclei of the medial hypothalamus. Aspartate is distributed rather uniformly with the highest concentration in the hypothalamic arcuate nucleus and the lowest in the midbrain central gray matter and the cerebellum. Acute formalin (pain) stress elevated glutamate and aspartate levels in the corical areas and substantia nigra significantly, but had minor or no effects on other brain nuclei. Increased locomotor and behavioral activities due to a high dose of amphetamine resulted in a 2-5-fold increases of glutamate and aspartate concentrations, particularly in the biogenic amine-containing brain nuclei.

Original languageEnglish
Pages (from-to)252-257
Number of pages6
JournalBrain research
Volume373
Issue number1-2
DOIs
Publication statusPublished - May 14 1986

Keywords

  • amphetamine
  • aspartate
  • brainstem nucleus
  • cerebral cortex
  • glutamate
  • hypothalamic nucleus
  • pain-stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats'. Together they form a unique fingerprint.

  • Cite this