Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats

M. Palkóvits, Tibor Láng, András Patthy, István Elekes

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Concentrations of glutamate and aspartate have been measured in 45 microdissected brain areas and nuclei in rat. Both amino acids are ubiquitously present and distributed unevenly in the central nervous system. Very high glutamate levels were found in the cerebellum and the insular cortex, high levels in neocortical and limbic cortical areas, and in the nuclei of the medial hypothalamus. Aspartate is distributed rather uniformly with the highest concentration in the hypothalamic arcuate nucleus and the lowest in the midbrain central gray matter and the cerebellum. Acute formalin (pain) stress elevated glutamate and aspartate levels in the corical areas and substantia nigra significantly, but had minor or no effects on other brain nuclei. Increased locomotor and behavioral activities due to a high dose of amphetamine resulted in a 2-5-fold increases of glutamate and aspartate concentrations, particularly in the biogenic amine-containing brain nuclei.

Original languageEnglish
Pages (from-to)252-257
Number of pages6
JournalBrain Research
Volume373
Issue number1-2
DOIs
Publication statusPublished - May 14 1986

Fingerprint

Aspartic Acid
Glutamic Acid
Brain
Cerebellum
Middle Hypothalamus
Periaqueductal Gray
Arcuate Nucleus of Hypothalamus
Biogenic Amines
Acute Pain
Substantia Nigra
Amphetamine
Locomotion
Cerebral Cortex
Formaldehyde
Central Nervous System
Amino Acids

Keywords

  • amphetamine
  • aspartate
  • brainstem nucleus
  • cerebral cortex
  • glutamate
  • hypothalamic nucleus
  • pain-stress

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats. / Palkóvits, M.; Láng, Tibor; Patthy, András; Elekes, István.

In: Brain Research, Vol. 373, No. 1-2, 14.05.1986, p. 252-257.

Research output: Contribution to journalArticle

Palkóvits, M. ; Láng, Tibor ; Patthy, András ; Elekes, István. / Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats. In: Brain Research. 1986 ; Vol. 373, No. 1-2. pp. 252-257.
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