Distribution and morphological features of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) activity in intrinsic neurons of the Oddi sphincter of the cat

Erzsébet Fehér, Catherine Montagnese

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To clarify the role of nitric oxide (NO) in the sphincter of Oddi, we histochemically investigated the distribution of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d), a marker for NO synthase, in the cat. NADPH-diaphorase activity was localized in two neuronal subtypes: large neurons with many dendrites and smaller with one process. Most of the nerve cell bodies (99%) in the wall of the sphincter of Oddi showed strong activity for this enzyme. The nerve fibers with NADPH-d activity were observed in all layers, chiefly in the muscle layers. These results suggest that NO may play a very important role in the neuronal regulation of sphincter of Oddi.

Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalNeuroscience Letters
Issue number1
Publication statusPublished - Mar 28 1994



  • Autonomic innervation
  • Cat
  • Nitric oxide
  • Sphincter of Oddi

ASJC Scopus subject areas

  • Neuroscience(all)

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