The distribution and elimination of fumonisins after oral administration of 50 mg FB1, 20 mg FB2 and 5 mg FB3 per animal day-1 for 22 days was studied in weaned barrows. At the end of the trial, the lung, heart, liver, kidney, spleen, brain, serum, bile, muscle, fat, urine and faeces samples were collected and their content of fumonisins (FB1, B2) determined by LC-MS. The highest FB1 concentrations were found in the liver (99.4±37.5 ng g-1) and kidneys (30.6±10.1 ng g-1), whilst the highest average amount of FB2 was in the liver (1.4±2.3 ng g-1) and fat (2.6 ng g-1±4.8) samples. Comparing the FB1/FB2 ratio in different organs (19/1), it was found that the ratio in the abdominal and subcutaneous fat samples (4/1) was markedly different from those in all other tissues, namely the relative proportion of FB2 was higher in latter cases. Of the total quantity of FB1, the 13% taken up during 5 days was excreted unchanged with the faeces and urine. On average, in the urine and faeces, FB1 was detected in nine- and 14-fold quantities, as compared with FB2.
ASJC Scopus subject areas
- Food Science
- Chemistry (miscellaneous)
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis