Distinguishing between cellular and vasogenic edema in head injured patients with focal lesions using magnetic resonance imaging.

A. Marmarou, G. Portella, P. Barzó, S. Signoretti, P. Fatouros, A. Beaumont, T. Jiang, R. Bullock

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Having determined that edema and not vascular engorgement is the major factor leading to traumatic brain swelling, the objective of this study was to determine which type of edema, cellular or vasogenic, is responsible for increased tissue water in patients with focal lesions. Severely head injured patients (GCS 8 or less) were transported to imaging suites for measurement of brain water and apparent diffusion coefficient (ADC) using magnetic resonance technique. Cerebral blood flow by stable Xenon method was also measured in the regions of interest. Brain water was increased significantly in the hemisphere with lesion. The increase in water was associated with reduced ADC signifying a predominant cellular edema. The ADC in the contralateral hemisphere was near normal value. Cerebral blood flow values in the regions of interest were above ischemic levels suggesting that factors other than ischemia are responsible for the cytotoxic swelling in patients with focal injury.

Original languageEnglish
Pages (from-to)349-351
Number of pages3
JournalActa Neurochirurgica, Supplement
Volume76
Publication statusPublished - 2000

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Edema
Cerebrovascular Circulation
Head
Magnetic Resonance Imaging
Water
Xenon
Brain Edema
Brain
Blood Vessels
Reference Values
Magnetic Resonance Spectroscopy
Ischemia
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Distinguishing between cellular and vasogenic edema in head injured patients with focal lesions using magnetic resonance imaging. / Marmarou, A.; Portella, G.; Barzó, P.; Signoretti, S.; Fatouros, P.; Beaumont, A.; Jiang, T.; Bullock, R.

In: Acta Neurochirurgica, Supplement, Vol. 76, 2000, p. 349-351.

Research output: Contribution to journalArticle

Marmarou, A, Portella, G, Barzó, P, Signoretti, S, Fatouros, P, Beaumont, A, Jiang, T & Bullock, R 2000, 'Distinguishing between cellular and vasogenic edema in head injured patients with focal lesions using magnetic resonance imaging.', Acta Neurochirurgica, Supplement, vol. 76, pp. 349-351.
Marmarou, A. ; Portella, G. ; Barzó, P. ; Signoretti, S. ; Fatouros, P. ; Beaumont, A. ; Jiang, T. ; Bullock, R. / Distinguishing between cellular and vasogenic edema in head injured patients with focal lesions using magnetic resonance imaging. In: Acta Neurochirurgica, Supplement. 2000 ; Vol. 76. pp. 349-351.
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AU - Jiang, T.

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