Distinction Between Graves' Disease and Hashimoto's Thyroiditis by Gene Profiling

L. Puskás, Laszlo Hackler, Ferenc Juhasz, A. Zvara, Nadir R. Farid

Research output: Contribution to journalArticle

Abstract

Using DNA microarray technology, we have investigated whether gene expression profiles of Graves' disease (GD) and Hashimoto's thyroiditis (HT) thyroid tissue is different to be disease-specific or overlap to make differentiation between the two condition difficult. We have identified 127 genes whose expression showed relative or absolute divergence between the two diseases. These genes related to immune function, innate or acquired, receptors, apoptosis, tumour suppressor genes, transport channels, signalling pathways, glycolipid-modifying enzymes or thyroid-specific. We found genes mapping to many chromosomal regions (3q27, 5q31-33, 7q31, 14q24.3-31, 18q21, 20q11.2, 20q13, Xp11, Xq21.33-22) previously mapped by genetic studies as relevant to the genetic susceptibility to autoimmune thyroid disease to be differentially expressed. Pursuing this paradigm further, we have identified for the first time a cluster of genes at 19q13.3-q13.4 which were differentially expressed in GD and HT. Our conclusions were recently corroborated by chromosome 19 sequencing which identified a cluster of immunoglobulin-like receptors important to immunity in that region. On the basis of gene profiling we show that GD and HT are distinct autoimmune disorders. DNA microarray is potentially a powerful tool in identifying candidate genes relevant to the susceptibility of common complex traits.

Original languageEnglish
Pages (from-to)9-24
Number of pages16
JournalInternational Journal on Disability and Human Development
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

Keywords

  • 19q13
  • DNA micoarray
  • gene expression
  • genetics
  • Graves' disease
  • Hashimoto's thyroiditis

ASJC Scopus subject areas

  • Rehabilitation
  • Sensory Systems
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Advanced and Specialised Nursing
  • Speech and Hearing

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