Distinction between Graves' disease and Hashimoto's thyroiditis by gene profiling

L. Puskás, Ferenc Juhasz, A. Zvara, Laszlo Hackler, Nadir R. Farid

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Using DNA microarray technology, we have investigated whether gene expression profiles of Graves' disease (GD) and Hashimoto's thyroiditis (HT) thyroid tissue is different to be disease-specific or overlap to make differentiation between the two condition difficult. We have identified 127 genes whose expression showed relative or absolute divergence between the two diseases. These genes related to immune function, innate or acquired, receptors, apoptosis, tumour suppressor genes, transport channels, signalling pathways, glycolipid-modifying enzymes or thyroid-specific. We found genes mapping to many chromosomal regions (3q27, 5q31-33, 7q31, 14q24.3-31, 18q21, 20q11.2, 20q13, Xp11, Xq21.33-22) previously mapped by genetic studies as relevant to the genetic susceptibility to autoimmune thyroid disease to be differentially expressed. Pursuing this paradigm further, we have identified for the first time a cluster of genes at 19q13.3-q13.4 which were differentially expressed in GD and HT. Our conclusions were recently corroborated by chromosome 19 sequencing which identified a cluster of immunoglobulin-like receptors important to immunity in that region. On the basis of gene profiling we show that GD and HT are distinct autoimmune disorders. DNA microarray is potentially a powerful tool in identifying candidate genes relevant to the susceptibility of common complex traits.

Original languageEnglish
Pages (from-to)9-23
Number of pages15
JournalJournal of Endocrine Genetics
Volume4
Issue number1
Publication statusPublished - 2005

Fingerprint

Hashimoto Disease
Graves Disease
Oligonucleotide Array Sequence Analysis
Thyroid Gland
Genes
Chromosomes, Human, Pair 19
Chromosome Mapping
Glycolipids
Thyroid Diseases
Genetic Predisposition to Disease
Multigene Family
Tumor Suppressor Genes
Transcriptome
Autoimmune Diseases
Immunoglobulins
Immunity
Apoptosis
Technology
Gene Expression
Enzymes

Keywords

  • 19q13
  • DNA micoarray
  • Gene expression
  • Genetics
  • Graves' disease
  • Hashimoto's thyroiditis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Endocrinology
  • Genetics

Cite this

Distinction between Graves' disease and Hashimoto's thyroiditis by gene profiling. / Puskás, L.; Juhasz, Ferenc; Zvara, A.; Hackler, Laszlo; Farid, Nadir R.

In: Journal of Endocrine Genetics, Vol. 4, No. 1, 2005, p. 9-23.

Research output: Contribution to journalArticle

Puskás, L. ; Juhasz, Ferenc ; Zvara, A. ; Hackler, Laszlo ; Farid, Nadir R. / Distinction between Graves' disease and Hashimoto's thyroiditis by gene profiling. In: Journal of Endocrine Genetics. 2005 ; Vol. 4, No. 1. pp. 9-23.
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