Distinct toll-like receptor expression in monocytes and T cells in chronic HCV infection

Angela Dolganiuc, Catherine Garcia, Karen Kodys, Gyongyi Szabo

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Aim: Hepatitis C virus often establishes chronic infections. Recent studies suggest that viral and bacterial infections are more common in HCV-infected patients compared to controls. Pathogens are recognized by Toll-like receptors (TLRs) to shape adaptive and innate immune responses. Methods: In this study, to assess the ability of HCV-infected host to recognize invading pathogens, we investigated Toll-like receptor expression in innate (monocytes) and adaptive (T cells) immune cells by real-time PCR. Results: We determined that RNA levels for TLRs 2, 6. 7, 8, 9 and 10 mRNA levels were upregulated in both monocytes and T cells in HCV-infected patients compared to controls. TLR4 was only upregulated in T lymphocytes, while TLR5 was selectively increased in monocytes of HCV-infected patients. MD-2, a TLR4 co-receptor, was increased in patients' monocytes and T cells while CD14 and MyD88 were increased only in monocytes. Conclusion: Our data reveal novel details on TLR expression that likely relates to innate recognition of pathogens and immune defense in HCV-infected individuals.

Original languageEnglish
Pages (from-to)1198-1204
Number of pages7
JournalWorld journal of gastroenterology
Volume12
Issue number8
DOIs
Publication statusPublished - Feb 28 2006

Keywords

  • Hepatitis C virus
  • Monocytes
  • T cells
  • Toll-like receptors

ASJC Scopus subject areas

  • Gastroenterology

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