Distinct receptors mediate gastrin-releasing peptide and neuromedin B-induced delay of gastric emptying of liquids in rats

G. Varga, Ralf Marco Liehr, Carmelo Scarpignato, David H. Coy

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The present study was carried out to define which bombesin receptors are involved in the delay of gastric emptying induced by bombesin-like peptides. Adult male rats were fitted with gastric and jugular vein cannulas. Gastric emptying was determined 5 min after a 3-ml intragastric load of 0.9 M NaCl using phenol red as a marker. Mammalian bombesin-like peptides gastrin-releasing peptide-10 and neuromedin B both induced a delay of gastric emptying. When [Phe6]bombesin-(6-13)-methyl ester, a selective antagonist of the gastrin-releasing peptide-preferring subtype of bombesin receptors, was injected 5 min before the agonists, the effect of gastrin-releasing peptide-10 was competitively inhibited, whereas that of neuromedin B remained unaffected. Our results indicate that gastrin-releasing peptide-10 and neuromedin B delay gastric emptying by acting on distinct receptors in rats, in vivo.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalEuropean Journal of Pharmacology
Volume286
Issue number1
DOIs
Publication statusPublished - Nov 3 1995

Fingerprint

Cholecystokinin B Receptor
Gastric Emptying
Bombesin
Bombesin Receptors
Gastrin-Releasing Peptide
Phenolsulfonphthalein
Peptides
Jugular Veins
Stomach
Esters
neuromedin B
peptide B
neuromedin C

Keywords

  • Bombesin
  • Bombesin receptor antagonist
  • Bombesin receptor subtype
  • Gastric emptying

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Distinct receptors mediate gastrin-releasing peptide and neuromedin B-induced delay of gastric emptying of liquids in rats. / Varga, G.; Liehr, Ralf Marco; Scarpignato, Carmelo; Coy, David H.

In: European Journal of Pharmacology, Vol. 286, No. 1, 03.11.1995, p. 109-112.

Research output: Contribution to journalArticle

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