Distinct phenotypes in mixed connective tissue disease: Subgroups and survival

P. Szodoray, A. Hajas, L. Kardos, B. Dezső, G. Soós, E. Zold, J. Vegh, I. Csípő, B. Nakken, M. Zeher, G. Szegedi, E. Bodolay

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The aim of the present study was to assess the autoantibody profile, dominant clinical symptoms and cluster characteristics of different Mixed connective tissue disease (MCTD phenotypes. Two-hundred-and-one patients with MCTD were followed-up longitudinally. Five clinical parameters, Raynaud's phenomenon, pulmonary artery hypertension (PAH), myositis, interstitial lung disease (ILD), erosive arthritis and five auto-antibodies besides anti-U1RNP, antiendothelial cell antibodies (AECA), anti-CCP, anti-cardiolipin (anti-CL), anti-SSA/SSB and IgM rheumatoid factor (RF) were selected for cluster analysis. The mean age of patients was 52.9±12.4 years and the mean follow-up of the disease was 12.5±7.2 years. Patients were classified into three cluster groups. Cluster 1 with 77 patients, cluster 2 with 79 patients and cluster 3 with 45 patients. In cluster 1 the prevalence of PAH (55.8%; p

Original languageEnglish
Pages (from-to)1412-1422
Number of pages11
JournalLupus
Volume21
Issue number13
DOIs
Publication statusPublished - Nov 2012

Fingerprint

Mixed Connective Tissue Disease
Phenotype
Survival
Pulmonary Hypertension
Pulmonary Artery
Raynaud Disease
Myositis
Cardiolipins
Rheumatoid Factor
Interstitial Lung Diseases
Autoantibodies
Arthritis
Immunoglobulin M
Cluster Analysis
Anti-Idiotypic Antibodies

Keywords

  • autoantibodies
  • cluster analysis
  • Mixed connective tissue disease
  • phenotypes

ASJC Scopus subject areas

  • Rheumatology

Cite this

Distinct phenotypes in mixed connective tissue disease : Subgroups and survival. / Szodoray, P.; Hajas, A.; Kardos, L.; Dezső, B.; Soós, G.; Zold, E.; Vegh, J.; Csípő, I.; Nakken, B.; Zeher, M.; Szegedi, G.; Bodolay, E.

In: Lupus, Vol. 21, No. 13, 11.2012, p. 1412-1422.

Research output: Contribution to journalArticle

Szodoray, P. ; Hajas, A. ; Kardos, L. ; Dezső, B. ; Soós, G. ; Zold, E. ; Vegh, J. ; Csípő, I. ; Nakken, B. ; Zeher, M. ; Szegedi, G. ; Bodolay, E. / Distinct phenotypes in mixed connective tissue disease : Subgroups and survival. In: Lupus. 2012 ; Vol. 21, No. 13. pp. 1412-1422.
@article{fcd23105104d440eaea49800cdf394a3,
title = "Distinct phenotypes in mixed connective tissue disease: Subgroups and survival",
abstract = "The aim of the present study was to assess the autoantibody profile, dominant clinical symptoms and cluster characteristics of different Mixed connective tissue disease (MCTD phenotypes. Two-hundred-and-one patients with MCTD were followed-up longitudinally. Five clinical parameters, Raynaud's phenomenon, pulmonary artery hypertension (PAH), myositis, interstitial lung disease (ILD), erosive arthritis and five auto-antibodies besides anti-U1RNP, antiendothelial cell antibodies (AECA), anti-CCP, anti-cardiolipin (anti-CL), anti-SSA/SSB and IgM rheumatoid factor (RF) were selected for cluster analysis. The mean age of patients was 52.9±12.4 years and the mean follow-up of the disease was 12.5±7.2 years. Patients were classified into three cluster groups. Cluster 1 with 77 patients, cluster 2 with 79 patients and cluster 3 with 45 patients. In cluster 1 the prevalence of PAH (55.8{\%}; p",
keywords = "autoantibodies, cluster analysis, Mixed connective tissue disease, phenotypes",
author = "P. Szodoray and A. Hajas and L. Kardos and B. Dezső and G. So{\'o}s and E. Zold and J. Vegh and I. Cs{\'i}pő and B. Nakken and M. Zeher and G. Szegedi and E. Bodolay",
year = "2012",
month = "11",
doi = "10.1177/0961203312456751",
language = "English",
volume = "21",
pages = "1412--1422",
journal = "Lupus",
issn = "0961-2033",
publisher = "SAGE Publications Ltd",
number = "13",

}

TY - JOUR

T1 - Distinct phenotypes in mixed connective tissue disease

T2 - Subgroups and survival

AU - Szodoray, P.

AU - Hajas, A.

AU - Kardos, L.

AU - Dezső, B.

AU - Soós, G.

AU - Zold, E.

AU - Vegh, J.

AU - Csípő, I.

AU - Nakken, B.

AU - Zeher, M.

AU - Szegedi, G.

AU - Bodolay, E.

PY - 2012/11

Y1 - 2012/11

N2 - The aim of the present study was to assess the autoantibody profile, dominant clinical symptoms and cluster characteristics of different Mixed connective tissue disease (MCTD phenotypes. Two-hundred-and-one patients with MCTD were followed-up longitudinally. Five clinical parameters, Raynaud's phenomenon, pulmonary artery hypertension (PAH), myositis, interstitial lung disease (ILD), erosive arthritis and five auto-antibodies besides anti-U1RNP, antiendothelial cell antibodies (AECA), anti-CCP, anti-cardiolipin (anti-CL), anti-SSA/SSB and IgM rheumatoid factor (RF) were selected for cluster analysis. The mean age of patients was 52.9±12.4 years and the mean follow-up of the disease was 12.5±7.2 years. Patients were classified into three cluster groups. Cluster 1 with 77 patients, cluster 2 with 79 patients and cluster 3 with 45 patients. In cluster 1 the prevalence of PAH (55.8%; p

AB - The aim of the present study was to assess the autoantibody profile, dominant clinical symptoms and cluster characteristics of different Mixed connective tissue disease (MCTD phenotypes. Two-hundred-and-one patients with MCTD were followed-up longitudinally. Five clinical parameters, Raynaud's phenomenon, pulmonary artery hypertension (PAH), myositis, interstitial lung disease (ILD), erosive arthritis and five auto-antibodies besides anti-U1RNP, antiendothelial cell antibodies (AECA), anti-CCP, anti-cardiolipin (anti-CL), anti-SSA/SSB and IgM rheumatoid factor (RF) were selected for cluster analysis. The mean age of patients was 52.9±12.4 years and the mean follow-up of the disease was 12.5±7.2 years. Patients were classified into three cluster groups. Cluster 1 with 77 patients, cluster 2 with 79 patients and cluster 3 with 45 patients. In cluster 1 the prevalence of PAH (55.8%; p

KW - autoantibodies

KW - cluster analysis

KW - Mixed connective tissue disease

KW - phenotypes

UR - http://www.scopus.com/inward/record.url?scp=84867826641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867826641&partnerID=8YFLogxK

U2 - 10.1177/0961203312456751

DO - 10.1177/0961203312456751

M3 - Article

C2 - 22864236

AN - SCOPUS:84867826641

VL - 21

SP - 1412

EP - 1422

JO - Lupus

JF - Lupus

SN - 0961-2033

IS - 13

ER -