Epidemiologic data in praeeclampsia have shown an increased risk of infants with both high- or low birth weights suggesting a heterogenous pathogenesis of the disease. In this retrospective study gestational indices of 37 praeeclamptic patients with distinct neonatal birth weights (average or higher, n=23 and lower-than-average, n=14) were compared and correlation between birth weight and continuous indices were analysed. In the high-birth-weight group a higher value of cardiac output (p<0.001), cardiac index (p<0.001), maternal age (p=0.046), weight (p<0.001), and body mass index (p=0.001), and gestational age at delivery (p=0.035) were found. In the low-birth-weight group hypertension appeared earlier (p<0.001), maximum proteinuria and vascular resistance were higher (p=0.015 and p=0.002, respectively), and signs of fetal deterioration such as oligohydramnios (in 71.4%), and pathological findings of Doppler flow or CTG (in 50%) occured only in this group, therefore labor induction was more frequent (p=0.007). No difference was found between the study groups according to maximum mean arterial pressure and hematocrit, gestational weight gain, and incidence of operative delivery. Fetal birth weight correlated with maternal weight gain (p=0.012) and marginally with maximum mean arterial pressure (p=0.052) in the high-birth-weight group and inversely with maximum proteinuria (p=0.029) in the low-birth-weight group. These data support the hypothesis that praeeclampsia is not a homogenous disease. The relative risk of birth weightaverege significantly increases by cardiac output 7.45 l/min (odds ratio=16.5 and 95% confidence intervals=3.2, 45.8) determined within the 32-40 weeks. Measurement of cardiac output during the last trimester may help to evaluate the outcome of pregnancy and choose a better strategy of the management.
|Number of pages||5|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2003|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology