Distinct clonal origin of low-grade MALT-type and high-grade lesions of a multifocal gastric lymphoma

A. Matolcsy, M. Nagy, N. Kisfaludy, G. Kelényi

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25 Citations (Scopus)

Abstract

Aims: Low-grade mucosa-associated lymphoid tissue (MALT) lymphoma and high-grade B-cell non-Hodgkin's lymphoma (NHL) of the stomach may occur simultaneously. To determine the clonal relationship between these tumours, we compared the immunoglobulin heavy chain gene (IgH) rearrangements of low and high-grade components of a multifocal gastric NHL. Methods and results: The complementary determining region 3 (CDR3) of the IgH gene rearrangements were polymerase chain reaction (PCR) amplified, cloned and sequenced. The analysis of the CDR3 sequences rearranged by tumour cells of low-grade MALT and the high-grade NHL revealed different nucleic acid sequences. Conclusion: These findings suggest that low-grade MALT and high-grade B-cell components of multifocal gastric NHL may represent unrelated clones.

Original languageEnglish
Pages (from-to)6-8
Number of pages3
JournalHistopathology
Volume34
Issue number1
DOIs
Publication statusPublished - Feb 1 1999

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Keywords

  • Clonality
  • High-grade transformation
  • Ig gene
  • MALT-type lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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