Dissolution profile of novel composite pellet cores based on different ratios of microcrystalline cellulose and isomalt

Oliver Luhn, Nikolett Kállai, Zsombor Kristóf Nagy, Kristóf Kovács, Bodo Fritzsching, I. Klebovich, I. Antal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

There is a growing interest towards the application of inert cores as starting materials for pharmaceutical pellet manufacturing. They serve as alternatives to develop and adapt a relatively simple manufacturing technology compared with an extrusion/spheronisation process. The major objective of this study was to investigate the effect of the compositions of core materials on the drug release profile. Pure microcrystalline cellulose (MCC), isomalt and different types of novel composite MCC-isomalt cores were layered with model drug (sodium diclofenac) and were coated with acrylic polymer. The effect of the osmolality in the gastrointestinal tract was simulated using glucose as osmotically active agent during in vitro dissolution tests. The results demonstrated the dependence of drug dissolution profile on the ratio of MCC and isomalt in the core and the influence of osmotic properties of the dissolution medium. Isomalt used in the composite core was able to decrease the vulnerability of the dissolution kinetics to the changes in the osmotic environment.

Original languageEnglish
Pages (from-to)2675-2680
Number of pages6
JournalJournal of Pharmaceutical Sciences
Volume101
Issue number8
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Diclofenac
Pharmaceutical Preparations
Osmolar Concentration
Gastrointestinal Tract
Polymers
Technology
Glucose
Palatinit
microcrystalline cellulose
Drug Liberation
In Vitro Techniques

Keywords

  • Dissolution
  • Drug delivery systems
  • Excipients
  • Factorial design
  • Inert pellet core
  • Isomalt
  • Microcrystalline cellulose
  • Osmolality
  • Solid dosage form

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Dissolution profile of novel composite pellet cores based on different ratios of microcrystalline cellulose and isomalt. / Luhn, Oliver; Kállai, Nikolett; Nagy, Zsombor Kristóf; Kovács, Kristóf; Fritzsching, Bodo; Klebovich, I.; Antal, I.

In: Journal of Pharmaceutical Sciences, Vol. 101, No. 8, 08.2012, p. 2675-2680.

Research output: Contribution to journalArticle

Luhn, Oliver ; Kállai, Nikolett ; Nagy, Zsombor Kristóf ; Kovács, Kristóf ; Fritzsching, Bodo ; Klebovich, I. ; Antal, I. / Dissolution profile of novel composite pellet cores based on different ratios of microcrystalline cellulose and isomalt. In: Journal of Pharmaceutical Sciences. 2012 ; Vol. 101, No. 8. pp. 2675-2680.
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