Dissociation of presynaptic α2-adrenoceptors following prazosin administration: Presynaptic effect of prazosin

E. Vízi, Nándor Ludvig, A. Rónai, Gábor Folly

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Evidence has been obtained that prazosin possesses a presynaptic α2-adrenoceptor blocking action in the rat vas deferens preparation stimulated at 1 Hz. In the presence of prazosin yohimbine failed to affect the presynaptic α2-adrenoceptor stimulatory effect of 1-noradrenaline while the effect of xylazine was almost completely abolished. It is therefore suggested that there are two kinetically different prejunctional α2-adrenoceptor sites.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalEuropean Journal of Pharmacology
Volume95
Issue number3-4
DOIs
Publication statusPublished - Nov 25 1983

Fingerprint

Prazosin
Adrenergic Receptors
Xylazine
Vas Deferens
Yohimbine
Norepinephrine

Keywords

  • Prazosin
  • Rat vas deferens
  • Two prejunctional α-adrenoceptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Dissociation of presynaptic α2-adrenoceptors following prazosin administration : Presynaptic effect of prazosin. / Vízi, E.; Ludvig, Nándor; Rónai, A.; Folly, Gábor.

In: European Journal of Pharmacology, Vol. 95, No. 3-4, 25.11.1983, p. 287-290.

Research output: Contribution to journalArticle

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