Dissociation between medial temporal lobe and basal ganglia memory systems in schizophrenia

S. Kéri, Orsolya Nagy, O. Kelemen, Catherine E. Myers, Mark A. Gluck

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The purpose of this study was to investigate basal ganglia (BG) and medial temporal lobe (MTL) dependent learning in patients with schizophrenia. Acquired equivalence is a phenomenon in which prior training to treat two stimuli as equivalent (if two stimuli are associated with the same response) increases generalization between them. The learning of stimulus-response pairs is related to the BG, whereas the MTL system participates in stimulus generalization. Forty-three patients with DSM-IV schizophrenia and 28 matched healthy controls participated. Volunteers received the Rutgers acquired equivalence task (face-fish task) by Myers et al. (2003) [Myers, C.E., Shohamy, D., Gluck, M.A. et al., 2003. Dissociating hippocampal versus basal ganglia contributions to learning and transfer. J. Cogn. Neurosci. 15, 185-193.], the California Verbal Learning Test (CVLT), and the n-back working memory test. The Rutgers acquired equivalence task investigates BG-dependent processes (stimulus-response learning) and MTL-dependent processes (stimulus generalization) with a single test. Results revealed that patients with schizophrenia showed a selective deficit on stimulus generalization, whereas stimulus-response learning was spared. The stimulus generalization deficit correlated with the CVLT performance (total scores from trials 1-5 and long-delay recall), but not with the n-back test performance. The number of errors during stimulus-response learning correlated with the daily chlorpromazine-equivalent dose of antipsychotics. In conclusion, this is the first study to show that patients with schizophrenia exhibit deficits during MTL-dependent learning, but not during BG-dependent learning within a single task. High-dose first generation antipsychotics may disrupt BG-dependent learning by blocking dopaminergic neurotransmission in the nigro-stiratal system.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalSchizophrenia Research
Volume77
Issue number2-3
DOIs
Publication statusPublished - Sep 15 2005

Fingerprint

Temporal Lobe
Basal Ganglia
Schizophrenia
Stimulus Generalization
Learning
Verbal Learning
Antipsychotic Agents
Response Generalization
Chlorpromazine
Short-Term Memory
Synaptic Transmission
Diagnostic and Statistical Manual of Mental Disorders
Volunteers
Fishes

Keywords

  • Acquired equivalence
  • Antipsychotics
  • Basal ganglia
  • Learning
  • Medial temporal lobe
  • Memory
  • Parkinsonism
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Dissociation between medial temporal lobe and basal ganglia memory systems in schizophrenia. / Kéri, S.; Nagy, Orsolya; Kelemen, O.; Myers, Catherine E.; Gluck, Mark A.

In: Schizophrenia Research, Vol. 77, No. 2-3, 15.09.2005, p. 321-328.

Research output: Contribution to journalArticle

Kéri, S. ; Nagy, Orsolya ; Kelemen, O. ; Myers, Catherine E. ; Gluck, Mark A. / Dissociation between medial temporal lobe and basal ganglia memory systems in schizophrenia. In: Schizophrenia Research. 2005 ; Vol. 77, No. 2-3. pp. 321-328.
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