Disruption of amyloid aggregates by artificial ferritins

L. Balejčíková, V. I. Petrenko, M. Baťková, K. Šipošová, V. M. Garamus, L. A. Bulavin, M. V. Avdeev, L. Almásy, P. Kopčanský

Research output: Contribution to journalArticle

Abstract

Presence of protein amyloid aggregates is associated with many neurodegenerative disorders, such as Alzheimer's disease etc. The effect of magnetoferritin and reconstructed ferritin on the structure of lysozyme amyloid aggregates was studied using small-angle X-ray scattering, atomic force microscopy and thioflavin T fluorescence measurements. It has been shown that both magnetoferritin and reconstructed ferritin molecules affect the size, structure and amount of the amyloid fibrils. We assume that the anti-amyloid effect of magnetoferritin and reconstructed ferritin is due to the presence of iron in solutions but is not associated with the magnetic character of the iron oxide phases, i.e. magnetite/maghemite for magnetoferritin and ferrihydrite for ferritin.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume473
DOIs
Publication statusPublished - Mar 1 2019

Fingerprint

Ferritins
Amyloid
lysozyme
Magnetite
Ferrosoferric Oxide
X ray scattering
Amyloidogenic Proteins
Iron oxides
iron oxides
magnetite
Atomic force microscopy
Muramidase
Enzymes
Fluorescence
atomic force microscopy
disorders
Iron
proteins
iron
fluorescence

Keywords

  • Amyloid aggregates
  • Anti-amyloid effect
  • Disruption of amyloid
  • Ferritin
  • Interactions between amyloid and magnetic materials
  • Magnetoferritin

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Balejčíková, L., Petrenko, V. I., Baťková, M., Šipošová, K., Garamus, V. M., Bulavin, L. A., ... Kopčanský, P. (2019). Disruption of amyloid aggregates by artificial ferritins. Journal of Magnetism and Magnetic Materials, 473, 215-220. https://doi.org/10.1016/j.jmmm.2018.10.055

Disruption of amyloid aggregates by artificial ferritins. / Balejčíková, L.; Petrenko, V. I.; Baťková, M.; Šipošová, K.; Garamus, V. M.; Bulavin, L. A.; Avdeev, M. V.; Almásy, L.; Kopčanský, P.

In: Journal of Magnetism and Magnetic Materials, Vol. 473, 01.03.2019, p. 215-220.

Research output: Contribution to journalArticle

Balejčíková, L, Petrenko, VI, Baťková, M, Šipošová, K, Garamus, VM, Bulavin, LA, Avdeev, MV, Almásy, L & Kopčanský, P 2019, 'Disruption of amyloid aggregates by artificial ferritins', Journal of Magnetism and Magnetic Materials, vol. 473, pp. 215-220. https://doi.org/10.1016/j.jmmm.2018.10.055
Balejčíková L, Petrenko VI, Baťková M, Šipošová K, Garamus VM, Bulavin LA et al. Disruption of amyloid aggregates by artificial ferritins. Journal of Magnetism and Magnetic Materials. 2019 Mar 1;473:215-220. https://doi.org/10.1016/j.jmmm.2018.10.055
Balejčíková, L. ; Petrenko, V. I. ; Baťková, M. ; Šipošová, K. ; Garamus, V. M. ; Bulavin, L. A. ; Avdeev, M. V. ; Almásy, L. ; Kopčanský, P. / Disruption of amyloid aggregates by artificial ferritins. In: Journal of Magnetism and Magnetic Materials. 2019 ; Vol. 473. pp. 215-220.
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