Disruption of amyloid aggregates by artificial ferritins

L. Balejčíková, V. I. Petrenko, M. Baťková, K. Šipošová, V. M. Garamus, L. A. Bulavin, M. V. Avdeev, L. Almásy, P. Kopčanský

Research output: Contribution to journalArticle

Abstract

Presence of protein amyloid aggregates is associated with many neurodegenerative disorders, such as Alzheimer's disease etc. The effect of magnetoferritin and reconstructed ferritin on the structure of lysozyme amyloid aggregates was studied using small-angle X-ray scattering, atomic force microscopy and thioflavin T fluorescence measurements. It has been shown that both magnetoferritin and reconstructed ferritin molecules affect the size, structure and amount of the amyloid fibrils. We assume that the anti-amyloid effect of magnetoferritin and reconstructed ferritin is due to the presence of iron in solutions but is not associated with the magnetic character of the iron oxide phases, i.e. magnetite/maghemite for magnetoferritin and ferrihydrite for ferritin.

LanguageEnglish
Pages215-220
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume473
DOIs
Publication statusPublished - Mar 1 2019

Fingerprint

Neurodegenerative diseases
Ferrosoferric Oxide
Magnetic materials
Ferritins
X ray scattering
Amyloid
Atomic force microscopy
Amyloidogenic Proteins
Muramidase
Iron
Fluorescence
Molecules
magnetoferritin
ferric oxide

Keywords

  • Amyloid aggregates
  • Anti-amyloid effect
  • Disruption of amyloid
  • Ferritin
  • Interactions between amyloid and magnetic materials
  • Magnetoferritin

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Balejčíková, L., Petrenko, V. I., Baťková, M., Šipošová, K., Garamus, V. M., Bulavin, L. A., ... Kopčanský, P. (2019). Disruption of amyloid aggregates by artificial ferritins. Journal of Magnetism and Magnetic Materials, 473, 215-220. https://doi.org/10.1016/j.jmmm.2018.10.055

Disruption of amyloid aggregates by artificial ferritins. / Balejčíková, L.; Petrenko, V. I.; Baťková, M.; Šipošová, K.; Garamus, V. M.; Bulavin, L. A.; Avdeev, M. V.; Almásy, L.; Kopčanský, P.

In: Journal of Magnetism and Magnetic Materials, Vol. 473, 01.03.2019, p. 215-220.

Research output: Contribution to journalArticle

Balejčíková, L, Petrenko, VI, Baťková, M, Šipošová, K, Garamus, VM, Bulavin, LA, Avdeev, MV, Almásy, L & Kopčanský, P 2019, 'Disruption of amyloid aggregates by artificial ferritins' Journal of Magnetism and Magnetic Materials, vol. 473, pp. 215-220. https://doi.org/10.1016/j.jmmm.2018.10.055
Balejčíková L, Petrenko VI, Baťková M, Šipošová K, Garamus VM, Bulavin LA et al. Disruption of amyloid aggregates by artificial ferritins. Journal of Magnetism and Magnetic Materials. 2019 Mar 1;473:215-220. https://doi.org/10.1016/j.jmmm.2018.10.055
Balejčíková, L. ; Petrenko, V. I. ; Baťková, M. ; Šipošová, K. ; Garamus, V. M. ; Bulavin, L. A. ; Avdeev, M. V. ; Almásy, L. ; Kopčanský, P. / Disruption of amyloid aggregates by artificial ferritins. In: Journal of Magnetism and Magnetic Materials. 2019 ; Vol. 473. pp. 215-220.
@article{9f93d5ea366f4bfb81fbc3dce2841a99,
title = "Disruption of amyloid aggregates by artificial ferritins",
abstract = "Presence of protein amyloid aggregates is associated with many neurodegenerative disorders, such as Alzheimer's disease etc. The effect of magnetoferritin and reconstructed ferritin on the structure of lysozyme amyloid aggregates was studied using small-angle X-ray scattering, atomic force microscopy and thioflavin T fluorescence measurements. It has been shown that both magnetoferritin and reconstructed ferritin molecules affect the size, structure and amount of the amyloid fibrils. We assume that the anti-amyloid effect of magnetoferritin and reconstructed ferritin is due to the presence of iron in solutions but is not associated with the magnetic character of the iron oxide phases, i.e. magnetite/maghemite for magnetoferritin and ferrihydrite for ferritin.",
keywords = "Amyloid aggregates, Anti-amyloid effect, Disruption of amyloid, Ferritin, Interactions between amyloid and magnetic materials, Magnetoferritin",
author = "L. Balejč{\'i}kov{\'a} and Petrenko, {V. I.} and M. Baťkov{\'a} and K. Šipošov{\'a} and Garamus, {V. M.} and Bulavin, {L. A.} and Avdeev, {M. V.} and L. Alm{\'a}sy and P. Kopčansk{\'y}",
year = "2019",
month = "3",
day = "1",
doi = "10.1016/j.jmmm.2018.10.055",
language = "English",
volume = "473",
pages = "215--220",
journal = "Journal of Magnetism and Magnetic Materials",
issn = "0304-8853",
publisher = "Elsevier",

}

TY - JOUR

T1 - Disruption of amyloid aggregates by artificial ferritins

AU - Balejčíková, L.

AU - Petrenko, V. I.

AU - Baťková, M.

AU - Šipošová, K.

AU - Garamus, V. M.

AU - Bulavin, L. A.

AU - Avdeev, M. V.

AU - Almásy, L.

AU - Kopčanský, P.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Presence of protein amyloid aggregates is associated with many neurodegenerative disorders, such as Alzheimer's disease etc. The effect of magnetoferritin and reconstructed ferritin on the structure of lysozyme amyloid aggregates was studied using small-angle X-ray scattering, atomic force microscopy and thioflavin T fluorescence measurements. It has been shown that both magnetoferritin and reconstructed ferritin molecules affect the size, structure and amount of the amyloid fibrils. We assume that the anti-amyloid effect of magnetoferritin and reconstructed ferritin is due to the presence of iron in solutions but is not associated with the magnetic character of the iron oxide phases, i.e. magnetite/maghemite for magnetoferritin and ferrihydrite for ferritin.

AB - Presence of protein amyloid aggregates is associated with many neurodegenerative disorders, such as Alzheimer's disease etc. The effect of magnetoferritin and reconstructed ferritin on the structure of lysozyme amyloid aggregates was studied using small-angle X-ray scattering, atomic force microscopy and thioflavin T fluorescence measurements. It has been shown that both magnetoferritin and reconstructed ferritin molecules affect the size, structure and amount of the amyloid fibrils. We assume that the anti-amyloid effect of magnetoferritin and reconstructed ferritin is due to the presence of iron in solutions but is not associated with the magnetic character of the iron oxide phases, i.e. magnetite/maghemite for magnetoferritin and ferrihydrite for ferritin.

KW - Amyloid aggregates

KW - Anti-amyloid effect

KW - Disruption of amyloid

KW - Ferritin

KW - Interactions between amyloid and magnetic materials

KW - Magnetoferritin

UR - http://www.scopus.com/inward/record.url?scp=85055031504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055031504&partnerID=8YFLogxK

U2 - 10.1016/j.jmmm.2018.10.055

DO - 10.1016/j.jmmm.2018.10.055

M3 - Article

VL - 473

SP - 215

EP - 220

JO - Journal of Magnetism and Magnetic Materials

T2 - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

SN - 0304-8853

ER -