Disparate effects of naloxone in hypothalamic amenorrhoea of athletes.

E. Szabó, J. Annus, S. Zalányi, G. Falkay

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Of 30 amenorrhoeic women athletes, 28 were considered to have hypothalamic amenorrhoea according to their low gonadotropin, estradiol (E2) and normal testosterone and prolactin (PRL) values. Gonadotropin-releasing hormone (LH-RH 100 micrograms i.v.) and naloxone (4 mg i.v. bolus followed by 2.8 mg/h infusion) tests were administered consecutively. Fifteen subjects reacted to the naloxone test with at least a fivefold increase in LH values; these values were consistently above those of the LH-RH test. The other 13 women reacted similarly to the releasing hormone but not to naloxone. While there were no differences between basal LH values in the two groups, E2 levels tended to be lower in non-responders, but since 1/3 of the values fell below the threshold of sensitivity of the E2 assay, no significance could be calculated. The obvious difference among the subjects could be E2 -mediated, the non-responders representing a deeper level of hypothalamic amenorrhoea. The naloxone test seems to be useful for differentiating between different forms of this condition.

Original languageEnglish
Pages (from-to)315-321
Number of pages7
JournalFunctional Neurology
Volume2
Issue number3
Publication statusPublished - Jul 1987

Fingerprint

Amenorrhea
Naloxone
Athletes
Gonadotropin-Releasing Hormone
Gonadotropins
Prolactin
Testosterone
Estradiol
Hormones

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Disparate effects of naloxone in hypothalamic amenorrhoea of athletes. / Szabó, E.; Annus, J.; Zalányi, S.; Falkay, G.

In: Functional Neurology, Vol. 2, No. 3, 07.1987, p. 315-321.

Research output: Contribution to journalArticle

Szabó, E, Annus, J, Zalányi, S & Falkay, G 1987, 'Disparate effects of naloxone in hypothalamic amenorrhoea of athletes.', Functional Neurology, vol. 2, no. 3, pp. 315-321.
Szabó, E. ; Annus, J. ; Zalányi, S. ; Falkay, G. / Disparate effects of naloxone in hypothalamic amenorrhoea of athletes. In: Functional Neurology. 1987 ; Vol. 2, No. 3. pp. 315-321.
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