Disorders of biotransformation during the progression of alcoholic liver disease.

T. Horváth, A. Pár, T. Past, T. Beró, Z. Tapsonyi, I. Kádas

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Biotransformation capacity was investigated in patients with various degrees of alcoholic liver damage. Aim of the investigation was to study the impairment of biotransformating ability during progression of liver damage. Four groups of patients with various liver diseases (alcoholic fatty liver, chronic persistent hepatitis, chronic active hepatitis, alcoholic cirrhosis) and two groups as controls were studied. The investigations were carried out with exogenous test substances (antipyrine, menthol and sulphadimidine) and by determination of D-glucaric acid excretion. It has been concluded that the depression of biotransformating ability in patients with alcoholic liver diseases is progressing during development of diseases. The changes in various metabolic pathways are different, and they seem to be more marked in the first phase of biotransformation than in the second phases.

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalActa Medica Hungarica
Volume43
Issue number4
Publication statusPublished - 1986

Fingerprint

Alcoholic Liver Diseases
Biotransformation
Chronic Hepatitis
Glucaric Acid
Alcoholic Fatty Liver
Menthol
Antipyrine
Alcoholic Liver Cirrhosis
Liver
Metabolic Networks and Pathways
Liver Diseases
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Horváth, T., Pár, A., Past, T., Beró, T., Tapsonyi, Z., & Kádas, I. (1986). Disorders of biotransformation during the progression of alcoholic liver disease. Acta Medica Hungarica, 43(4), 351-357.

Disorders of biotransformation during the progression of alcoholic liver disease. / Horváth, T.; Pár, A.; Past, T.; Beró, T.; Tapsonyi, Z.; Kádas, I.

In: Acta Medica Hungarica, Vol. 43, No. 4, 1986, p. 351-357.

Research output: Contribution to journalArticle

Horváth, T, Pár, A, Past, T, Beró, T, Tapsonyi, Z & Kádas, I 1986, 'Disorders of biotransformation during the progression of alcoholic liver disease.', Acta Medica Hungarica, vol. 43, no. 4, pp. 351-357.
Horváth, T. ; Pár, A. ; Past, T. ; Beró, T. ; Tapsonyi, Z. ; Kádas, I. / Disorders of biotransformation during the progression of alcoholic liver disease. In: Acta Medica Hungarica. 1986 ; Vol. 43, No. 4. pp. 351-357.
@article{9c257aeb6d57447b9d8fb6ec6368b72a,
title = "Disorders of biotransformation during the progression of alcoholic liver disease.",
abstract = "Biotransformation capacity was investigated in patients with various degrees of alcoholic liver damage. Aim of the investigation was to study the impairment of biotransformating ability during progression of liver damage. Four groups of patients with various liver diseases (alcoholic fatty liver, chronic persistent hepatitis, chronic active hepatitis, alcoholic cirrhosis) and two groups as controls were studied. The investigations were carried out with exogenous test substances (antipyrine, menthol and sulphadimidine) and by determination of D-glucaric acid excretion. It has been concluded that the depression of biotransformating ability in patients with alcoholic liver diseases is progressing during development of diseases. The changes in various metabolic pathways are different, and they seem to be more marked in the first phase of biotransformation than in the second phases.",
author = "T. Horv{\'a}th and A. P{\'a}r and T. Past and T. Ber{\'o} and Z. Tapsonyi and I. K{\'a}das",
year = "1986",
language = "English",
volume = "43",
pages = "351--357",
journal = "Acta Medica Hungarica",
issn = "0236-5286",
publisher = "Akademiai Kiado",
number = "4",

}

TY - JOUR

T1 - Disorders of biotransformation during the progression of alcoholic liver disease.

AU - Horváth, T.

AU - Pár, A.

AU - Past, T.

AU - Beró, T.

AU - Tapsonyi, Z.

AU - Kádas, I.

PY - 1986

Y1 - 1986

N2 - Biotransformation capacity was investigated in patients with various degrees of alcoholic liver damage. Aim of the investigation was to study the impairment of biotransformating ability during progression of liver damage. Four groups of patients with various liver diseases (alcoholic fatty liver, chronic persistent hepatitis, chronic active hepatitis, alcoholic cirrhosis) and two groups as controls were studied. The investigations were carried out with exogenous test substances (antipyrine, menthol and sulphadimidine) and by determination of D-glucaric acid excretion. It has been concluded that the depression of biotransformating ability in patients with alcoholic liver diseases is progressing during development of diseases. The changes in various metabolic pathways are different, and they seem to be more marked in the first phase of biotransformation than in the second phases.

AB - Biotransformation capacity was investigated in patients with various degrees of alcoholic liver damage. Aim of the investigation was to study the impairment of biotransformating ability during progression of liver damage. Four groups of patients with various liver diseases (alcoholic fatty liver, chronic persistent hepatitis, chronic active hepatitis, alcoholic cirrhosis) and two groups as controls were studied. The investigations were carried out with exogenous test substances (antipyrine, menthol and sulphadimidine) and by determination of D-glucaric acid excretion. It has been concluded that the depression of biotransformating ability in patients with alcoholic liver diseases is progressing during development of diseases. The changes in various metabolic pathways are different, and they seem to be more marked in the first phase of biotransformation than in the second phases.

UR - http://www.scopus.com/inward/record.url?scp=0022828060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022828060&partnerID=8YFLogxK

M3 - Article

C2 - 3601579

AN - SCOPUS:0022828060

VL - 43

SP - 351

EP - 357

JO - Acta Medica Hungarica

JF - Acta Medica Hungarica

SN - 0236-5286

IS - 4

ER -