Disordered visual processing and oscillatory brain activity in autism and Williams syndrome

Sarah J. Grice, Michael W. Spratling, Annette Karmiloff-Smith, Hanife Halit, Gergely Csibra, Michelle De Haan, Mark H. Johnson

Research output: Contribution to journalArticle

253 Citations (Scopus)

Abstract

Two developmental disorders, autism and Williams syndrome, are both commonly described as having difficulties in integrating perceptual features, i.e. binding spatially separate elements into a whole. It is already known that healthy adults and infants display electroencephalographic (EEG) γ-band bursts (around 40 Hz) when the brain is required to achieve such binding. Here we explore γ-band EEG in autism and Williams Syndrome and demonstrate differential abnormalities in the two phenotypes. We show that despite putative processing similarities at the cognitive level, binding in Williams syndrome and autism can be dissociated at the neurophysiological level by different abnormalities in underlying brain oscillatory activity. Our study is the first to identify that binding-related γ EEG can be disordered in humans.

Original languageEnglish
Pages (from-to)2697-2700
Number of pages4
JournalNeuroreport
Volume12
Issue number12
DOIs
Publication statusPublished - Aug 28 2001

Keywords

  • Autism
  • Binding
  • EEG
  • ERP
  • Face processing
  • Visual perception
  • Williams Syndrome
  • γ

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Grice, S. J., Spratling, M. W., Karmiloff-Smith, A., Halit, H., Csibra, G., De Haan, M., & Johnson, M. H. (2001). Disordered visual processing and oscillatory brain activity in autism and Williams syndrome. Neuroreport, 12(12), 2697-2700. https://doi.org/10.1097/00001756-200108280-00021